- Tel: 858.663.9055
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
IRF3 Antibody [clone 1522CT766.58.24] (F54481)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
 |
F54481-0.2ML | In 1X PBS, pH 7.4, with 0.09% sodium azide | 0.2 ml | 399 | |
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F54481-0.05ML | In 1X PBS, pH 7.4, with 0.09% sodium azide | 0.05 ml | 185 |
| Availability | 1-3 business days |
| Species Reactivity | Human, Monkey |
| Format | Purified |
| Clonality | Monoclonal (mouse origin) |
| Isotype | IgG1,k |
| Clone Name | 1522CT766.58.24 |
| Purity | Protein G affinity |
| UniProt | Q14653 |
| Localization | Cytoplasmic, nuclear |
| Applications | Western blot : 1:500-1:2000 Immunohistochemistry (FFPE) : 1:25 Flow cytometry : 1:25 (1x10e6 cells) Immunofluorescence : 1:25 |
| Limitations | This IRF3 antibody is available for research use only. |
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Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, is phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes. Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in primary macrophages.
The stated application concentrations are suggested starting points. Titration of the IRF3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Recombinant human protein was used as the immunogen for the IRF3 antibody.
Aliquot the IRF3 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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