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Home >> Antibodies >> INTS14 Antibody / Integrator complex subunit 14

INTS14 Antibody / Integrator complex subunit 14 (RQ8862)

  Catalog No Formulation Size Price (USD)  
Image RQ8862 0.5mg/ml if reconstituted with 0.2ml sterile DI water 100 ug 439
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Western blot testing of human 1) 293T, 2) HaCaT, 3) Jurkat and 4) RT4 cell lysate with INTS14 antibody. Predicted molecular weight ~57 kDa.
Availability 1-2 days
Species Reactivity Human
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit IgG
Purity Antigen affinity chromatography
Buffer Lyophilized from 1X PBS with 2% Trehalose
UniProt Q96SY0
Applications Western Blot : 1-2ug/ml
ELISA : 0.1-0.5ug/ml
Limitations This INTS14 antibody is available for research use only.
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Description

INTS14 is a subunit of the integrator complex, a complex of proteins involved in the 3' end processing of small nuclear RNAs (snRNAs) and other non-coding RNAs. This process is crucial for the maturation and stability of these transcripts, ultimately affecting gene expression and regulation. INTS14 is believed to play a key role in coordinating the activities of other integrator complex subunits, ensuring efficient and accurate processing of RNA. INTS14 interacts with key proteins involved in RNA processing, suggesting a direct role in regulating gene expression. Additionally, mutations in INTS14 have been linked to certain types of cancer, highlighting its potential as a therapeutic target.

Application Notes

Optimal dilution of the INTS14 antibody should be determined by the researcher.

Immunogen

An E.coli-derived human recombinant protein (amino acids R27-H271) was used as the immunogen for the INTS14 antibody.

Storage

After reconstitution, the INTS14 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

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