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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
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IL6ST Antibody IL6ST/4101 recognizes interleukin 6 signal transducer (IL6ST), a transmembrane glycoprotein widely known as gp130 and CD130. IL6ST functions as the common signal-transducing receptor component for members of the interleukin 6 cytokine family. It associates with ligand-specific receptor components to form signaling complexes responsive to cytokines including IL-6, IL-11, leukemia inhibitory factor, oncostatin M, ciliary neurotrophic factor, and cardiotrophin-1.
In classical IL-6 signaling, IL-6 first binds IL6R (CD126), followed by recruitment of IL6ST to form the active receptor complex. IL6ST also participates in IL-6 trans-signaling, in which IL-6 bound to soluble IL6R can activate gp130-expressing cells that lack membrane-bound IL6R. The broad distribution of IL6ST therefore enables IL-6 family cytokines to regulate diverse cellular and physiological processes.
Assembly of IL6ST-containing receptor complexes activates associated JAK kinases and downstream signaling pathways including STAT3, MAPK, and PI3K-AKT. These pathways influence cell survival, proliferation, differentiation, hematopoiesis, inflammatory responses, and tissue homeostasis. Negative regulatory mechanisms, including SOCS proteins, help constrain the duration and magnitude of IL6ST-mediated signaling.
Clone IL6ST/4101 is a mouse monoclonal antibody generated against a recombinant fragment corresponding to the extracellular domain of human IL6ST. The antibody has also been evaluated on a HuProt protein microarray containing more than 19,000 full-length human proteins to assess target specificity. As an Interleukin 6 Receptor Beta Antibody, clone IL6ST/4101 provides a defined reagent for investigating the shared receptor component linking IL-6 family cytokines with intracellular signaling. NSJ Bioreagents supplies IL6ST/4101 for research use only.
An IL6ST Antibody can be used to investigate gp130 expression and molecular mechanisms connecting IL-6 family cytokines with JAK-STAT signaling, inflammatory responses, immune regulation, and cellular homeostasis.
For a CD130 antibody with broader Western blot and IHC validation across multiple human samples, see our CD130 Antibody / gp130 Antibody page.
Optimal dilution of the IL6ST Antibody IL6ST/4101 / Interleukin 6 Receptor Beta Antibody should be determined by the researcher.
A recombinant fragment of the human protein corresponding to the extracellular domain was used as the immunogen for the IL6ST Antibody IL6ST/4101.
Aliquot the IL6ST Antibody IL6ST/4101 and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
IL6ST antibody, interleukin 6 signal transducer antibody, interleukin-6 signal transducer antibody, interleukin 6 receptor beta antibody, interleukin-6 receptor beta antibody, interleukin 6 receptor subunit beta antibody, CD130 antibody, gp130 antibody, IL6RB antibody
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