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Home >> Antibodies >> Interleukin 6 Receptor subunit beta Antibody / IL6ST / CD130

Interleukin 6 Receptor subunit beta Antibody / IL6ST / CD130 [clone IL6ST/4101] (V9656)

  Catalog No Formulation Size Price (USD)  
Image V9656-100UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 100 ug 519
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V9656-20UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 20 ug 229
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V9656SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 519
Microvalidated
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Analysis of HuProt(TM) microarray containing more than 19,000 full-length human proteins using Interleukin 6 Receptor subunit beta antibody (clone IL6ST/4101). These results demonstrate the foremost specificity of the IL6ST/4101 mAb. Z- and S- score: The Z-score represents the strength of a signal that an antibody (in combination with a fluorescently-tagged anti-IgG secondary Ab) produces when binding to a particular protein on the HuProt(TM) array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If the targets on the HuProt(TM) are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-scores. The S-score therefore represents the relative target specificity of an Ab to its intended target.
IHC staining of FFPE human adrenal gland tissue with Interleukin 6 Receptor subunit beta antibody (clone IL6ST/4101). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
Availability 1-3 business days
Species Reactivity Human
Format Purified
Clonality Monoclonal (mouse origin)
Isotype Mouse IgG2b, kappa
Clone Name IL6ST/4101
Purity Protein A/G affinity
UniProt P40189
Applications Immunohistochemistry (FFPE) : 1-2ug/ml
Limitations This Interleukin 6 Receptor subunit beta antibody is available for research use only.
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  • Applications : WB, IHC-P
    Reactivity : Human

Description

IL6ST is a signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize IL6ST for initiating signal transmission. Binding of IL6 to IL6R induces IL6ST homodimerization and formation of a high-affinity receptor complex, which activates the intracellular JAK-MAPK and JAK-STAT3 signaling pathways. [UniProt]

Application Notes

Optimal dilution of the Interleukin 6 Receptor subunit beta antibody should be determined by the researcher.

Immunogen

A recombinant fragment of the human protein corresponding to the extracellular domain was used as the immunogen for the Interleukin 6 Receptor subunit beta antibody.

Storage

Aliquot the Interleukin 6 Receptor subunit beta antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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