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Home >> Antibodies >> Interleukin 4 Antibody / IL-4

Interleukin 4 Antibody / IL-4 [clone IL4/1597] (V7884)

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  Catalog No Formulation Size Price (USD)  
Image V7884-100UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide 100 ug 519
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V7884-20UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide 20 ug 229
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V7884SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 519
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SDS-PAGE analysis of purified, BSA-free Interleukin 4 antibody (clone IL4/1597) as confirmation of integrity and purity.
SDS-PAGE analysis of purified, BSA-free Interleukin 4 antibody (clone IL4/1597) as confirmation of integrity and purity.
Availability 1-3 business days
Species Reactivity Human
Format Purified
Clonality Monoclonal (mouse origin)
Isotype Mouse IgG2b, kappa
Clone Name IL4/1597
Purity Protein G affinity chromatography
UniProt P07750
Applications ELISA (order BSA-free format for coating) :
Limitations This Interleukin 4 antibody is available for research use only.
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Description

Interleukin-4 (IL-4), also designated B cell stimulatory factor-1, is a glycosylated cytokine secreted by activated T lymphocytes, basophils and mast cells. The secreted IL-4 protein promotes the growth and differentiation of cells that participate in immune defense by favoring such events as the expansion of the Th2 lineage relative to Th1 cells. These T helper cell subsets are defined by their pattern of cytokine secretion: Th1 cells secrete IL-2, TNF, while Th2 cells secrete IL-4, IL-5 and IL-10. Another key immunological function of IL-4 is to induce immunoglobulin class switching. IL-4 has been shown to induce the production of IgE and enhance IgG4 secretion by B cells, but suppress the production of IgM, IgA, IgG1, IgG2 and IgG3. It has been determined that Stat6 is rapidly tyrosine phosphorylated following stimulation of IL-3 or IL-4, but is not detectably phosphorylated following stimulation with IL-2, IL-12 or erythropoietin.

Application Notes

Optimal dilution of the Interleukin 4 antibody should be determined by the researcher.

Immunogen

Recombinant full-length human IL-4 protein was used as the immunogen for this Interleukin 4 antibody.

Storage

Store the Interleukin 4 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

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