- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Interleukin-3 Receptor Alpha Antibody IL3RA/1822 / Interleukin-3 Receptor Alpha Chain Antibody [clone IL3RA/1822] (V5922)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V5922-100UG | 0.2 mg/ml in 1X PBS with 0.05% BSA, 0.05% sodium azide | 100 ug | 559 | |
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V5922-20UG | 0.2 mg/ml in 1X PBS with 0.05% BSA, 0.05% sodium azide | 20 ug | 259 | |
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V5922SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
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| Species Reactivity | Hamster, Human, Mouse, Rat |
| Format | Purified |
| Host | Mouse |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG2b, kappa |
| Clone Name | IL3RA/1822 |
| UniProt | P26951 |
| Localization | Membrane |
| Applications | Western Blot : 2-4ug/ml |
| Limitations | This Interleukin-3 Receptor Alpha Antibody IL3RA/1822 / Interleukin-3 Receptor Alpha Chain Antibody is available for research use only. |
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Interleukin-3 Receptor Alpha Antibody IL3RA/1822 recognizes IL3RA, a type I transmembrane glycoprotein also known as CD123. Encoded by the IL3RA gene, this protein forms the ligand-binding alpha subunit of the interleukin 3 receptor and contributes to regulation of hematopoietic cell survival, proliferation, and differentiation. CD123 expression among hematopoietic progenitors and multiple immune-cell populations reflects the importance of IL-3 responsiveness in blood-cell development and immune regulation.
IL3RA binds IL-3 with relatively low affinity when expressed independently. Association with the common beta subunit CSF2RB (CD131) produces the functional high-affinity IL-3 receptor complex. CSF2RB is also shared by receptor systems for GM-CSF and IL-5. Formation of the functional receptor enables activation of intracellular pathways including JAK-STAT, PI3K-AKT, and MAPKs, connecting cytokine recognition with changes in cellular survival, proliferation, and differentiation.
Interleukin 3 receptor alpha expression is associated with hematopoietic progenitor cells and several myeloid and immune-cell populations. The Interleukin-3 Receptor Alpha Chain Antibody target CD123 is also studied extensively in hematologic malignancies, particularly myeloid neoplasms in which altered or elevated receptor expression can occur. Its cell-surface localization and role in cytokine responsiveness make IL3RA relevant to research examining normal hematopoiesis, immune-cell development, and malignant hematopoietic populations.
Clone IL3RA/1822 is a mouse monoclonal antibody generated against a recombinant fragment corresponding to approximately amino acids 26-171 of human IL3RA. As an Interleukin-3 Receptor Alpha Chain Antibody, clone IL3RA/1822 provides a defined monoclonal reagent for investigating CD123 and its relationship to hematopoietic and immune-cell biology. NSJ Bioreagents supplies IL3RA/1822 for research use only.
An Interleukin-3 Receptor Alpha Antibody can be used to investigate IL3RA expression and molecular mechanisms connecting IL-3 receptor signaling, hematopoietic development, immune regulation, and hematologic disease.
For a mouse monoclonal clone with broader IHC validation and exceptionally strong protein microarray target separation, see our CD123 Antibody IL3RA/1531 / IL3RA Monoclonal Antibody page.
Optimal dilution of the Interleukin-3 Receptor Alpha Antibody IL3RA/1822 / Interleukin-3 Receptor Alpha Chain Antibody should be determined by the researcher.
A recombinant fragment of human IL3RA protein (around amino acids 26-171) (exact sequence is proprietary) was used as the immunogen for the Interleukin-3 Receptor Alpha Antibody IL3RA/1822.
Interleukin-3 Receptor Alpha Antibody IL3RA/1822 with sodium azide - store at 2 to 8oC; antibody without sodium azide - store at -20 to -80oC.
CD123 antibody, IL3RA antibody, IL-3RA antibody, IL3R alpha antibody, IL-3R alpha antibody, interleukin 3 receptor alpha antibody, interleukin-3 receptor alpha antibody, interleukin 3 receptor alpha chain antibody, interleukin-3 receptor alpha chain antibody
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![Western blot testing of Jurkat [A] and MOLT4 [B] lysates with CD123 antibody at 2ug/ml. Predicted molecular weight ~43kDa.](https://www.nsjbio.com/plp/thumb_image/img-R35737-100UG-1.jpg?v=1790374153 "Western blot testing of Jurkat [A] and MOLT4 [B] lysates with CD123 antibody at 2ug/ml. Predicted molecular weight ~43kDa.")
