- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Interleukin-3 receptor alpha chain Antibody / Interleukin 3 receptor alpha [clone IL3RA/1822] (V5922)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V5922-100UG | 0.2 mg/ml in 1X PBS with 0.05% BSA, 0.05% sodium azide | 100 ug | 559 | |
|
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V5922-20UG | 0.2 mg/ml in 1X PBS with 0.05% BSA, 0.05% sodium azide | 20 ug | 259 | |
|
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V5922SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
|
| Species Reactivity | Hamster, Human, Mouse, Rat |
| Format | Purified |
| Host | Mouse |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG2b, kappa |
| Clone Name | IL3RA/1822 |
| UniProt | P26951 |
| Localization | Membrane |
| Applications | Western Blot : 2-4ug/ml |
| Limitations | This Interleukin-3 receptor alpha chain antibody is available for research use only. |
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Interleukin-3 receptor alpha chain antibody targets Interleukin 3 receptor alpha, a type I transmembrane cytokine receptor subunit that serves as the ligand-binding component of the interleukin-3 receptor complex. Interleukin-3 receptor alpha chain is primarily localized to the cell surface and associates with the shared beta chain to enable intracellular signaling following cytokine engagement. This receptor system plays an important role in regulating hematopoietic cell survival, proliferation, and differentiation during immune development and homeostasis.
Interleukin 3 receptor alpha chain expression is dynamically regulated across hematopoietic lineages and developmental stages. The receptor is expressed on hematopoietic stem and progenitor cells, monocytes, basophils, plasmacytoid dendritic cells, and select immune cell populations, reflecting its involvement in early immune cell specification and functional maturation. Because of this expression pattern, antibody-based detection of Interleukin 3 receptor alpha chain is widely used in research examining cytokine responsiveness, lineage commitment, and immune cell differentiation within the hematopoietic system.
Signaling through Interleukin 3 receptor alpha influences multiple intracellular pathways associated with cell survival and proliferative capacity following cytokine stimulation. These signaling events contribute to immune cell expansion and maintenance under both physiological and disease-associated conditions. Altered expression of Interleukin 3 receptor alpha chain has been reported in hematologic disorders, including myeloid neoplasms, where increased receptor expression is frequently observed on malignant cell populations. As a result, Interleukin-3 receptor alpha chain antibody reagents are commonly applied in studies investigating dysregulated cytokine signaling and immune cell abnormalities in disease models.
Beyond disease-focused research, Interleukin 3 receptor alpha chain remains relevant to broader investigations of immune activation, inflammatory signaling, and cytokine-driven cellular responses. Because receptor expression reflects cytokine sensitivity rather than antigen specificity, antibody-based detection provides insight into immune signaling potential across diverse experimental contexts. Clone IL3RA/1822 is designed to recognize Interleukin 3 receptor alpha chain and supports research applications focused on immune regulation, hematopoiesis, and cytokine receptor biology. NSJ Bioreagents offers this antibody for research use.
Optimal dilution of the Interleukin-3 receptor alpha chain antibody should be determined by the researcher.
A recombinant fragment of human IL3RA protein (around amino acids 26-171) (exact sequence is proprietary) was used as the immunogen for the Interleukin-3 receptor alpha chain antibody.
Interleukin-3 receptor alpha chain antibody with sodium azide - store at 2 to 8oC; antibody without sodium azide - store at -20 to -80oC.
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