- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
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Interleukin 3 Antibody IL3/4004 recognizes interleukin 3 (IL-3), a cytokine encoded by the IL3 gene that regulates the growth, survival, and differentiation of hematopoietic cells. IL-3 is produced primarily by activated T cells and contributes to communication between immune cells and developing blood-cell populations. Its broad effects on hematopoietic progenitors and differentiated immune cells make IL-3 an important regulator of hematopoiesis and immune responses.
IL-3 exerts its effects through a heterodimeric receptor composed of the IL-3-specific alpha subunit IL3RA (CD123) and the common beta subunit CSF2RB (CD131). The beta subunit is also shared by the receptors for GM-CSF and IL-5. Formation of the functional IL-3 receptor activates intracellular pathways including JAK-STAT, PI3K-AKT, and MAPKs, promoting cellular survival, proliferation, and differentiation in responsive hematopoietic populations.
IL-3 can influence multiple myeloid and lymphoid lineages and has been studied for its effects on hematopoietic progenitor cells, mast cells, basophils, eosinophils, monocytes, and other immune-cell populations. Through these activities, IL-3 contributes to hematopoietic development, host defense, inflammatory responses, and regulation of immune-cell production. Altered IL-3 signaling has also been investigated in hematologic disorders and mechanisms affecting leukocyte expansion and survival.
Clone IL3/4004 is a mouse monoclonal antibody generated against recombinant human IL-3. The antibody has also been evaluated on a HuProt protein microarray containing more than 19,000 full-length human proteins to assess target specificity. As an IL3 Antibody, clone IL3/4004 provides a defined monoclonal reagent for investigating this hematopoietic and immunoregulatory cytokine. NSJ Bioreagents supplies IL3/4004 for research use only.
An Interleukin 3 Antibody can be used to investigate IL-3 expression and molecular mechanisms connecting cytokine signaling, hematopoietic cell development, immune-cell regulation, and inflammatory responses.
Explore our Immunology Antibodies page for additional antibodies targeting cytokines and regulators of immune-cell development and signaling.
Optimal dilution of the Interleukin 3 Antibody IL3/4004 / IL3 Antibody should be determined by the researcher.
A recombinant protein fragment was used as the immunogen for the Interleukin 3 Antibody IL3/4004.
Aliquot the Interleukin 3 Antibody IL3/4004 and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
IL3 antibody, IL-3 antibody, interleukin 3 antibody, interleukin-3 antibody, multipotent colony-stimulating factor antibody, multi-CSF antibody, mast cell growth factor antibody, MCGF antibody
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