- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
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IL-15 Antibody recognizes interleukin 15 (IL-15), an immunoregulatory cytokine encoded by the IL15 gene that contributes to the development, survival, proliferation, and activation of several immune-cell populations. IL-15 is particularly important for natural killer (NK) cells and memory CD8-positive T cells and also influences additional lymphocyte populations. Although IL-15 shares certain biological activities with IL-2, the two cytokines perform distinct roles in immune regulation and lymphocyte homeostasis.
IL-15 signals through a receptor complex containing IL15RA together with IL2RB and IL2RG, the latter two receptor subunits also being used by IL-2. A distinctive feature of IL-15 biology is trans-presentation, in which IL-15 bound to IL15RA on one cell is presented to IL2RB/IL2RG on an adjacent responding cell. Receptor engagement activates JAK1 and JAK3 and downstream signaling pathways that include STAT3 and STAT5, supporting lymphocyte proliferation, survival, and effector functions.
IL-15 is produced by several immune and non-immune cell populations, including monocytes, macrophages, dendritic cells, and stromal cells. Its production and availability are tightly regulated, helping coordinate immune-cell expansion and activation. IL-15 is widely studied in innate and adaptive immunity, infectious disease, inflammatory conditions, transplantation biology, and cancer immunology. Its prominent effects on NK cells and memory T cells have also generated interest in manipulating the IL-15 signaling axis to enhance or suppress specific immune responses.
This Interleukin 15 Polyclonal Antibody was generated against a recombinant fragment corresponding to amino acids 70-162 of human IL-15. The polyclonal format provides a population of antibodies recognizing the immunizing IL-15 region and offers a complementary reagent to monoclonal antibodies directed against this cytokine. NSJ Bioreagents supplies this antibody for research use only.
An IL-15 Antibody can be used to investigate IL-15 expression and its relationship to cytokine signaling, NK-cell biology, T-cell homeostasis, immune regulation, and inflammatory and antitumor immune responses.
For an IL-15 monoclonal with complementary Western blot, IHC, and protein microarray validation, see our IL15 Antibody IL15/4354 / Interleukin-15 Monoclonal Antibody page.
Optimal dilution of the IL-15 Antibody / Interleukin 15 Polyclonal Antibody should be determined by the researcher.
A human recombinant partial protein (amino acids D70-S162) was used as the immunogen for the IL-15 Antibody.
After reconstitution, the IL-15 Antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
IL15 antibody, interleukin 15 antibody, interleukin-15 antibody, IL-T antibody, interleukin T antibody
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