- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
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Interleukin 15 Antibody IL15/4696 recognizes interleukin 15 (IL-15), an immunoregulatory cytokine encoded by the IL15 gene. IL-15 contributes to the development, survival, proliferation, and activation of several lymphocyte populations and is particularly important for natural killer (NK) cells and memory CD8-positive T cells. Historically referred to as interleukin T (IL-T), IL-15 shares certain biological activities with IL-2 while performing distinct functions in immune-cell homeostasis and regulation.
IL-15 signals through a receptor system containing IL15RA together with IL2RB and IL2RG, the latter two subunits also being used by the IL-2 receptor. A characteristic feature of IL-15 biology is trans-presentation, during which IL-15 bound to IL15RA on one cell is presented to receptor subunits on an adjacent responding cell. This interaction activates JAK1 and JAK3 and downstream pathways that include STAT3 and STAT5, influencing lymphocyte survival, proliferation, and effector activity.
IL-15 is produced by several immune and non-immune cell populations, including monocytes, macrophages, dendritic cells, and stromal cells. Its production and presentation are tightly controlled, helping coordinate immune-cell responses without unchecked lymphocyte expansion. IL-15 is studied in innate and adaptive immunity, infectious disease, inflammatory conditions, cancer immunology, and mechanisms governing NK-cell and memory T-cell function. An IL-T Antibody can therefore support research into the cytokine historically identified as interleukin T and its role in immune regulation.
Clone IL15/4696 is a mouse monoclonal antibody generated against a recombinant fragment of human IL-15. This Interleukin 15 Antibody provides a defined reagent for investigating IL-15 expression and complements research examining cytokine-mediated control of lymphocyte biology. NSJ Bioreagents supplies clone IL15/4696 for research use only.
An Interleukin 15 Antibody can be used to investigate IL-15 expression and its relationship to cytokine signaling, NK-cell biology, T-cell homeostasis, immune regulation, and inflammatory and antitumor immune responses.
For an IL-15 monoclonal with complementary Western blot, IHC, and protein microarray validation, see our IL15 Antibody IL15/4354 / Interleukin-15 Monoclonal Antibody page.
Optimal dilution of the Interleukin 15 Antibody IL15/4696 / IL-T Antibody should be determined by the researcher.
A recombinant fragment of human IL15 was used as the immunogen for the Interleukin 15 Antibody IL15/4696.
Aliquot the Interleukin 15 Antibody IL15/4696 and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
IL-15 antibody, IL15 antibody, interleukin-15 antibody, IL-T antibody, interleukin T antibody
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