- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
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Interleukin-1 Receptor Antagonist Antibody IL1RA/4715 detects IL1RA/IL1RN protein. Two forms of interleukin-1, designated IL-1a and IL-1beta, have been described. Although encoded by distinct genes and exhibiting roughly only 25% sequence identity, IL-1a and IL-1beta bind to the same receptor and seem to elicit similar biological responses. IL-1 production is generally thought to be associated with inflammation, but it has also been shown to be expressed during kidney development, thymocyte differentiation and cartilage degradation. IL-1 plays a critical role in the regulation of immune response and inflammation acting as an activator of T and B lymphocytes and natural killer (NK) cells. IL-1 receptor antagonist (IL-1ra) is a cytokine that inhibits IL-1a and IL-1beta binding to interleukin receptors. By neutralizing the activity of IL-1, IL-1ra contributes to the inhibition of the immune and inflammatory responses and has been targeted as a drug for the treatment of severely active rheumatoid arthritis. There are four isoforms of IL-1ra that are produced as a result of alternative splicing events.
For a monoclonal clone with protein microarray specificity validation, see our IL1RN Antibody IL1RA/4716 / Interleukin-1 Receptor Antagonist Antibody page.
Optimal dilution of the Interleukin-1 Receptor Antagonist Antibody IL1RA/4715 / IL-1RA Monoclonal Antibody should be determined by the researcher.
A recombinant partial protein sequence (within amino acids 1-200) from the human protein was used as the immunogen for the Interleukin-1 Receptor Antagonist Antibody IL1RA/4715.
Aliquot the Interleukin-1 Receptor Antagonist Antibody IL1RA/4715 and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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