Interferon alpha Antibody 2.52 / Mouse Monoclonal [clone 2.52] (V2611)

Description

Interferon alpha Antibody 2.52 is specific for human interferon alpha 1 and does not cross react with human interferon alpha 2. Interferons are widely used therapeutic agents because of their anti-tumor and anti-viral effects and because of their modulatory effects on the immune system. These cytokines produce their effects by binding to the Type 1 Interferon alpha Receptor (IFNAR1). Down regulation of this receptor plays a key role in determining the magnitude and duration of cytokine signaling. This down regulation is influenced by phosphorylation of Serine 535 and 539 in the IFNAR1.

For an alternative monoclonal clone with documented specificity for IFNA1 without cross-reactivity to IFNA2, see our Interferon Alpha 1 Antibody IFNA/6689 / IFNA1 Antibody page.

Application Notes

Optimal dilution of the Interferon alpha Antibody 2.52 should be determined by the researcher.

1. This clone is also referred to as clone 2-52.

Immunogen

Purified recombinant human protein was used as the immunogen for the Interferon alpha antibody.

Storage

Store the Interferon alpha Antibody 2.52 at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).