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Home >> Antibodies >> Integrin linked kinase Antibody / ILK

Integrin linked kinase Antibody / ILK (R32407)

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Image R32407 0.5mg/ml if reconstituted with 0.2ml sterile DI water 100 ug 429
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Western blot testing of 1) rat lung, 2) mouse liver and 3) human HeLa lysate with Integrin linked kinase antibody. Expected molecular weight: 51-59 kDa.
Western blot testing of 1) rat lung, 2) mouse liver and 3) human HeLa lysate with Integrin linked kinase antibody. Expected molecular weight: 51-59 kDa.
Availability 1-3 business days
Species Reactivity Human, Mouse, Rat
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit IgG
Purity Antigen affinity
Buffer Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide
UniProt Q13418
Localization Cytoplasmic
Applications Western blot : 0.1-0.5ug/ml
Limitations This Integrin linked kinase antibody is available for research use only.
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Description

ILK, also known as Integrin-linked kinase, is a serine-threonine protein kinase. Transduction of extracellular matrix signals through integrins influences intracellular and extracellular functions, and appears to require interaction of integrin cytoplasmic domains with cellular proteins. Integrin-linked kinase (ILK) interacts with the cytoplasmic domain of beta-1 integrin. This gene was initially described to encode a serine/ threonine protein kinase with 4 ankyrin-like repeats, which associates with the cytoplasmic domain of beta integrins and acts as a proximal receptor kinase regulating integrin-mediated signal transduction. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. Recent results showed that ILK contains 5 ankyrin-like repeats, and that the C-terminal kinase domain is actually a pseudo-kinase with adaptor function.

Application Notes

Optimal dilution of the Integrin linked kinase antibody should be determined by the researcher.

Immunogen

Amino acids M1-H203 from the human protein were used as the immunogen for the Integrin linked kinase antibody.

Storage

After reconstitution, the Integrin linked kinase antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

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