- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Integrin Beta 4 Antibody UM-A9 / ITGB4 Monoclonal Antibody [clone UM-A9] (V2163)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V2163-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 100 ug | 559 | |
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V2163-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 20 ug | 259 | |
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V2163SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
|
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG2a, kappa |
| Clone Name | UM-A9 |
| Purity | Protein G affinity chromatography |
| Buffer | 1X PBS, pH 7.4 |
| Gene ID | 3691 |
| Localization | Cell surface |
| Applications | Flow Cytometry : 1-2ug/10^6 cells Immunofluorescence : 1-2ug/ml |
| Limitations | This Integrin Beta 4 Antibody UM-A9 / ITGB4 Monoclonal Antibody is available for research use only. |
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Integrin Beta 4 Antibody UM-A9 recognizes integrin beta 4, a transmembrane adhesion receptor subunit encoded by the ITGB4 gene and also designated CD104. ITGB4 is structurally distinct from other integrin beta chains and associates predominantly with integrin alpha 6 to form the alpha 6 beta 4 heterodimer. This receptor has important functions in epithelial attachment to basement membranes and is a major component of specialized adhesion structures known as hemidesmosomes.
Integrin beta 4 is a type I transmembrane glycoprotein distinguished by an exceptionally large cytoplasmic domain containing more than 1,000 amino acids. This intracellular region contains four fibronectin type III domains and multiple sites for interactions with cytoskeletal and signaling proteins. Its unusual structure allows alpha 6 beta 4 to provide stable mechanical adhesion while also participating in intracellular signaling pathways that influence cellular behavior.
Within hemidesmosomes, alpha 6 beta 4 connects epithelial cells to the underlying basement membrane. The extracellular portion of the receptor binds laminins, particularly laminin-332, while the ITGB4 cytoplasmic domain interacts with proteins including plectin and BP230. These interactions link the receptor complex to keratin intermediate filaments and help epithelial tissues resist mechanical stress.
CD104 also participates in signaling associated with cell migration, proliferation, survival, and tissue remodeling. Modification of the large ITGB4 cytoplasmic domain can alter interactions with hemidesmosomal proteins and contribute to receptor redistribution during cellular migration. Altered alpha 6 beta 4 expression and signaling have consequently been investigated in epithelial tumor progression, invasion, and changes in cell-matrix adhesion.
Pathogenic variants affecting ITGB4 can disrupt stable epithelial attachment and are associated with forms of junctional epidermolysis bullosa, including disease accompanied by pyloric atresia. These disorders demonstrate the importance of integrin beta 4 in maintaining epithelial-basement membrane adhesion and tissue integrity.
An Integrin Beta 4 Antibody such as clone UM-A9 provides a monoclonal reagent for investigating this distinctive integrin subunit, while an ITGB4 Monoclonal Antibody provides gene-based terminology for studies of CD104, hemidesmosomes, epithelial adhesion, and alpha 6 beta 4 biology.
For a broadly validated antibody targeting this protein, see our CD104 Antibody / ITGB4 Polyclonal Antibody page.
The concentration stated for each application is a general starting point. Variations in protocols, secondaries and substrates may require the Integrin Beta 4 Antibody UM-A9 / ITGB4 Monoclonal Antibody to be titered up or down for optimal performance.
The human squamous cell carcinoma line (UM-SCC1) was used as the immunogen for this Integrin Beta 4 Antibody UM-A9.
Store the Integrin Beta 4 Antibody UM-A9 at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
GP150; ITGB4, CD104 antibody, Integrin beta-4 antibodyCD104 antibody, ITGB4 antibody, Beta 4 Integrin antibody, Integrin beta-4 subunit antibody, GP150 antibody, CD104 antigen antibody
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