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Home >> Antibodies >> Insulin receptor substrate 2 Antibody / IRS2

Insulin receptor substrate 2 Antibody / IRS2 (RQ7182)

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  Catalog No Formulation Size Price (USD)  
Image RQ7182 0.5mg/ml if reconstituted with 0.2ml sterile DI water 100 ug 429
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Western blot testing of human 1) HeLa and 2) SH-SY5Y cell lysate with Insulin receptor substrate 2 antibody. Predicted molecular weight ~137 kDa but it may be observed at up to ~190 kDa due to phosphorylation.
Western blot testing of human 1) HeLa and 2) SH-SY5Y cell lysate with Insulin receptor substrate 2 antibody. Predicted molecular weight ~137 kDa but it may be observed at up to ~190 kDa due to phosphorylation.
Availability 1-3 business days
Species Reactivity Human
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit IgG
Purity Antigen affinity purified
Buffer Lyophilized from 1X PBS with 2% Trehalose
UniProt Q9Y4H2
Applications Western blot : 0.5-1ug/ml
Direct ELISA : 0.1-0.5ug/ml
Limitations This Insulin receptor substrate 2 antibody is available for research use only.
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Description

Insulin receptor substrate 2 (IRS2) is a protein that in humans is encoded by the IRS2 gene. It is mapped to 13q34. This gene encodes the insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines by acting as a molecular adaptor between diverse receptor tyrosine kinases and downstream effectors. The product of this gene is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation, as well as by an interleukin 4 receptor-associated kinase in response to IL4 treatment. IRS2 is expressed in many cells, it may be essential for signaling by several receptor systems.

Application Notes

Optimal dilution of the Insulin receptor substrate 2 antibody should be determined by the researcher.

Immunogen

Recombinant human protein (amino acids R83-E1338) was used as the immunogen for the Insulin receptor substrate 2 antibody.

Storage

After reconstitution, the Insulin receptor substrate 2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

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