- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
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Insulin-Like Growth Factor Binding Protein 3 Antibody recognizes IGFBP3, a secreted member of the insulin-like growth factor-binding protein family. IGFBP3, also known as IBP-3, binds insulin-like growth factors with high affinity and regulates their distribution, stability, and availability for receptor signaling. Through its interactions with IGF1 and IGF2, IGFBP3 can influence processes associated with cellular proliferation, differentiation, survival, and metabolism.
IGFBP3 is a major carrier of insulin-like growth factors in the circulation. Together with an IGF and the acid-labile subunit (ALS), it can form a ternary complex of approximately 140-150 kDa. Formation of this complex extends the circulating lifetime of IGFs and contributes to regulation of their availability to tissues. Proteolytic processing and interactions with other molecules can further influence the ability of IGFBP3 to bind and regulate insulin-like growth factors.
In addition to regulating IGF-dependent signaling, IGFBP3 has been investigated for biological activities that can occur independently of IGF sequestration. Protein interactions and intracellular localization may contribute to effects on proliferation, apoptosis, and transcriptional regulation. These functions have made IGFBP3 an extensively studied protein in research involving growth and development, metabolism, cellular stress responses, and cancer biology.
This mouse monoclonal antibody is derived from clone IGFBP3/3423 and has been characterized by protein microarray analysis. Protein Microarray Validated status provides additional characterization of antibody-target recognition across a large human protein panel. NSJ Bioreagents supplies this reagent for research investigating IGFBP3 expression and insulin-like growth factor regulation. An Insulin-Like Growth Factor Binding Protein 3 Antibody can support studies of IGFBP3 biology and mechanisms governing growth factor availability.
For a Protein Microarray Validated monoclonal targeting the same protein with a different clone, see our IGFBP3 Antibody IGFBP3/3424 / BP-53 Antibody page.
Optimal dilution of the Insulin-Like Growth Factor Binding Protein 3 Antibody / IBP-3 Antibody should be determined by the researcher.
Recombinant human full-length IGFBP3 protein was used as the immunogen for the Insulin-like growth factor-binding protein 3 antibody.
Aliquot the Insulin-like growth factor-binding protein 3 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
IGFBP3 antibody, Insulin-like growth factor-binding protein 3 antibody, IGFBP-3 antibody, IGF-binding protein 3 antibody, IBP-3 antibody, IBP3 antibody, BP-53 antibody
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