- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
INSM1 Antibody Recombinant Rabbit MAb / Insulinoma-associated 1 Antibody [clone INSM1/8122R] (V4820)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V4820-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
|
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V4820-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
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V4820SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
|
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Rabbit |
| Clonality | Recombinant Rabbit Monoclonal |
| Isotype | Rabbit IgG, kappa |
| Clone Name | INSM1/8122R |
| Purity | Protein A/G affinity |
| UniProt | Q01101 |
| Localization | Nucleus |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT |
| Limitations | This INSM1 antibody is available for research use only. |
|
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Insulinoma-associated protein 1 (INSM1) is a zinc finger transcription factor encoded by the INSM1 gene and plays a central role in the development and differentiation of neuroendocrine cells. The protein was originally identified in insulinoma tissue and is now widely recognized as a marker of neuroendocrine lineage. INSM1 Antibody Recombinant Rabbit MAb (clone INSM1/8122R) recognizes the INSM1 protein and is used to study expression of this transcription factor in neuroendocrine cells and tumors.
INSM1 functions as a transcriptional regulator that controls genes involved in endocrine cell differentiation, neuronal development, and hormone producing cell maturation. During embryonic development the protein is expressed in multiple neuroendocrine precursor populations including pancreatic endocrine progenitors and developing neuronal lineages. Because INSM1 activity is closely linked with neuroendocrine differentiation programs, its expression provides insight into the identity and developmental origin of endocrine cell populations.
The INSM1 protein localizes primarily to the nucleus, consistent with its role as a transcription factor. Nuclear localization allows clear visualization of INSM1 positive cells when analyzing tissue sections or cellular preparations. In normal adult tissues, expression is generally restricted to specialized neuroendocrine cell populations such as pancreatic islet cells, bronchial neuroendocrine cells, and scattered neuroendocrine cells within gastrointestinal epithelium. These restricted expression patterns make INSM1 a useful molecular indicator of neuroendocrine differentiation in biological samples.
In tumor biology, INSM1 expression is frequently associated with neuroendocrine neoplasms. Elevated levels have been observed in tumors such as small cell lung carcinoma, pulmonary neuroendocrine tumors, Merkel cell carcinoma, and pancreatic neuroendocrine tumors. Because many of these tumors retain transcriptional programs characteristic of neuroendocrine lineages, detection of INSM1 can provide insight into tumor cell identity and differentiation state.
Large scale tissue profiling studies further illustrate the selective distribution of INSM1 expression across human tissues. Analysis of diverse normal and cancer samples demonstrates strong expression in neuroendocrine tumor types while most non neuroendocrine epithelial tissues show minimal signal. These expression patterns highlight the biological specificity of the INSM1 transcription factor and its association with endocrine cell differentiation pathways.
INSM1 Antibody Recombinant Rabbit MAb (clone INSM1/8122R) is designed to recognize the INSM1 protein in research applications. The antibody supports studies investigating neuroendocrine differentiation, transcriptional regulation in endocrine cell lineages, and the molecular biology of neuroendocrine tumors.
Optimal dilution of the INSM1 Antibody Recombinant Rabbit MAb should be determined by the researcher.
A recombinant partial protein sequence (within amino acids 1-300) from the human protein was used as the immunogen for the INSM1 antibody.
Aliquot the INSM1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Insulinoma-associated 1 antibody, IA-1 antibody, Zinc finger protein INSM1 antibody, Insulinoma-associated transcription factor 1 antibody
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