- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
INHA Antibody Mouse Monoclonal INHA/9354 / Inhibin alpha INHA Antibody [clone INHA/9354] (V5751)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V5751-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
|
|
V5751-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
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V5751SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG2a, kappa |
| Clone Name | INHA/9354 |
| Purity | Protein G affinity |
| UniProt | P05111 |
| Localization | Cytoplasm |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml |
| Limitations | This Inhibin alpha chain/INHA antibody is available for research use only. |
|
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Inhibin subunit alpha (INHA) is a secreted glycoprotein hormone component encoded by the INHA gene and produced primarily by granulosa cells in the ovary and Sertoli cells in the testis. The protein is commonly referred to as Inhibin alpha and functions as part of the heterodimeric hormones inhibin A and inhibin B. INHA Antibody Mouse Monoclonal INHA/9354 recognizes the INHA protein and enables detection of inhibin alpha expression in studies examining reproductive biology and endocrine related tumors.
Inhibins belong to the transforming growth factor beta (TGF beta) superfamily of signaling molecules. The inhibin alpha subunit pairs with either the beta A or beta B subunit to form inhibin A or inhibin B respectively. These hormones function as endocrine regulators that suppress secretion of follicle stimulating hormone (FSH) from the anterior pituitary gland, thereby contributing to regulation of gonadal endocrine signaling and reproductive physiology.
In normal tissues, INHA expression is most prominent in ovarian granulosa cells and testicular Sertoli cells. The protein is synthesized as a precursor that undergoes proteolytic processing before secretion into the extracellular environment. Through its endocrine function, inhibin alpha participates in feedback regulation of reproductive hormone signaling and plays an important role in follicular development and spermatogenesis.
Expression of inhibin alpha has also been reported in several tumor types derived from endocrine or steroidogenic tissues. INHA expression has been observed in ovarian granulosa cell tumors, other sex cord stromal tumors, and certain adrenal cortical tumors. Detection of inhibin alpha protein therefore supports research investigating endocrine tumor biology and the differentiation of steroid producing tissues.
INHA Antibody Mouse Monoclonal INHA/9354 provides a reagent for detecting INHA protein in studies of gonadal development, reproductive hormone signaling, and endocrine tumor biology. Monoclonal antibodies recognize a defined epitope within the target antigen, enabling consistent antigen recognition and supporting investigation of inhibin alpha expression in molecular and cellular research systems.
Optimal dilution of the INHA Antibody Mouse Monoclonal INHA/9354 should be determined by the researcher.
A recombinant partial protein from human Inhibin alpha protein (within amino acids 233-362) was used as the immunogen for the Inhibin alpha chain/INHA antibody.
Aliquot the Inhibin alpha chain/INHA antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Inhibin alpha antibody, Inhibin alpha subunit antibody, INHA antibody, Inhibin A alpha antibody
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