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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Inhibin alpha Antibody Recombinant Rabbit MAb / Inhibin subunit alpha INHA Antibody [clone INHA/8872R] (V4954)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V4954-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
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V4954-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
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V4954SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Rabbit |
| Clonality | Recombinant Rabbit Monoclonal |
| Isotype | Rabbit IgG, kappa |
| Clone Name | INHA/8872R |
| Purity | Protein A/G affinity |
| UniProt | P05111 |
| Localization | Nucleus, Cytoplasm (secreted) |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT Western Blot : 2-4ug/ml |
| Limitations | This Inhibin alpha antibody is available for research use only. |
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Inhibin subunit alpha (INHA) is a secreted glycoprotein hormone component encoded by the INHA gene and produced primarily by granulosa cells in the ovary and Sertoli cells in the testis. The protein is commonly referred to as Inhibin alpha and functions as part of the dimeric hormones inhibin A and inhibin B. Inhibin alpha Antibody Recombinant Rabbit MAb (clone INHA/8872R) recognizes the INHA protein and enables detection of inhibin alpha expression in studies investigating reproductive biology and endocrine related tumors.
Inhibin proteins belong to the transforming growth factor beta (TGF beta) superfamily of signaling molecules. The inhibin alpha subunit forms heterodimeric complexes with one of two beta subunits, beta A or beta B, to generate inhibin A or inhibin B respectively. These hormones play an important endocrine role by suppressing secretion of follicle stimulating hormone (FSH) from the anterior pituitary gland, thereby regulating gonadal hormone signaling and reproductive physiology.
In normal tissues, INHA expression is most prominent in ovarian granulosa cells and testicular Sertoli cells. The protein is synthesized as a precursor molecule that undergoes proteolytic processing before secretion into the extracellular space. Because inhibin alpha participates in reproductive hormone regulation, its expression is largely associated with gonadal tissues and endocrine cell populations involved in steroidogenesis and reproductive function.
Inhibin alpha expression has also been observed in several tumor types derived from endocrine or steroidogenic tissues. Expression of INHA has been reported in ovarian granulosa cell tumors, other sex cord stromal tumors, and certain adrenal cortical tumors. Detection of inhibin alpha protein can therefore support studies investigating endocrine tumor biology and the differentiation of steroid producing cell types.
Inhibin alpha Antibody Recombinant Rabbit MAb (clone INHA/8872R) provides a reagent for detecting INHA protein in studies examining gonadal development, reproductive hormone regulation, and endocrine tumor biology. Recombinant monoclonal antibodies recognize a defined epitope within the target antigen, enabling consistent antigen recognition while supporting investigation of inhibin alpha expression in molecular and cellular research systems.
Optimal dilution of the Inhibin alpha Antibody Recombinant Rabbit MAb should be determined by the researcher.
A recombinant fragment of human Inhibin alpha protein (within amino acids 233-362) was used as the immunogen for the Inhibin alpha antibody.
Aliquot the Inhibin alpha antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
INHA antibody, Inhibin alpha subunit antibody, Inhibin A alpha antibody, Gonadal inhibin alpha antibody
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