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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Inhibin alpha Antibody Rabbit Polyclonal / Inhibin subunit alpha INHA Antibody (RQ5822)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
RQ5822 | 0.5mg/ml if reconstituted with 0.2ml sterile DI water | 100 ug | 449 |
| Availability | 1-3 business days |
| Species Reactivity | Human, Mouse, Rat |
| Format | Antigen affinity purified |
| Host | Rabbit |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit IgG |
| Purity | Affinity purified |
| Buffer | Lyophilized from 1X PBS with 2% Trehalose and 0.025% sodium azide |
| UniProt | P05111 |
| Applications | Western Blot : 0.5-1ug/ml Immunohistochemistry : 1-2ug/ml Immunofluorescence : 2-4ug/ml Flow Cytometry : 1-3ug/million cells Direct ELISA : 0.1-0.5ug/ml |
| Limitations | This Inhibin alpha antibody is available for research use only. |
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Inhibin subunit alpha (INHA) is a secreted glycoprotein hormone subunit encoded by the INHA gene and primarily produced by granulosa cells of the ovary and Sertoli cells of the testis. The protein is commonly referred to as Inhibin alpha and forms part of the dimeric hormones inhibin A and inhibin B. Inhibin alpha Antibody Rabbit Polyclonal recognizes the INHA protein and enables detection of inhibin alpha expression in studies investigating reproductive biology and endocrine tumors.
Inhibin proteins belong to the transforming growth factor beta (TGF beta) superfamily of signaling molecules. The alpha subunit combines with one of two beta subunits (beta A or beta B) to form the heterodimeric hormones inhibin A or inhibin B. These hormones function as endocrine regulators that suppress follicle stimulating hormone (FSH) secretion from the anterior pituitary gland, thereby participating in the regulation of reproductive hormone signaling and gonadal function.
In normal tissues, INHA expression is most prominent in ovarian granulosa cells and testicular Sertoli cells, where inhibin plays an important role in regulating follicular development and spermatogenesis. The protein is synthesized as a precursor that undergoes proteolytic processing before secretion into the extracellular environment. Because of its role in gonadal endocrine signaling, inhibin alpha expression is largely restricted to reproductive tissues and certain endocrine cell populations.
Inhibin alpha expression is also observed in several tumor types derived from steroid producing or sex cord stromal cells. Expression of INHA has been reported in ovarian sex cord stromal tumors, granulosa cell tumors, and certain adrenal cortical tumors. Detection of inhibin alpha can therefore support research investigating endocrine tumor biology and the cellular differentiation of steroidogenic tissues.
Inhibin alpha Antibody Rabbit Polyclonal provides a reagent for detecting INHA protein in studies of gonadal biology and endocrine related tumors. Polyclonal antibodies recognize multiple epitopes within the target protein, which can enhance antigen detection and support analysis of inhibin alpha expression in molecular and cellular research systems.
Optimal dilution of the Inhibin alpha Antibody Rabbit Polyclonal should be determined by the researcher.
Recombinant human protein (amino acids E254-I366) was used as the immunogen for the Inhibin alpha antibody.
After reconstitution, the Inhibin alpha antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
INHA antibody, Inhibin alpha subunit antibody, Inhibin A alpha antibody, Gonadal inhibin alpha antibody
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