- Tel: 858.663.9055
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Inhibin alpha Antibody / INHA (F54878)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
 |
F54878-0.4ML | In 1X PBS, pH 7.4, with 0.09% sodium azide | 0.4 ml | 399 | |
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F54878-0.08ML | In 1X PBS, pH 7.4, with 0.09% sodium azide | 0.08 ml | 185 |
| Availability | 1-3 business days |
| Species Reactivity | Human, Mouse |
| Format | Purified |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit Ig |
| Purity | Antigen affinity purified |
| UniProt | P05111 |
| Localization | Nuclear and Cytoplasmic (secreted) |
| Applications | Western blot : 1:500-1:1000 Flow cytometry : 1:10-1:50 (1x10e6 cells) Immunohistochemistry (FFPE) : 1:10-1:50 Immunofluorescence : 1:10-1:50 |
| Limitations | This Inhibin alpha antibody is available for research use only. |
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The inhibin alpha subunit joins either the beta A or beta B subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumour-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. However, in prostate cancer, expression of the inhibin alpha-subunit gene was suppressed and was not detectable in poorly differentiated tumor cells. Furthermore, because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone.
The stated application concentrations are suggested starting points. Titration of the Inhibin alpha antibody may be required due to differences in protocols and secondary/substrate sensitivity.
A portion of amino acids 79-108 from the human protein was used as the immunogen for the Inhibin alpha antibody.
Aliquot the Inhibin alpha antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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