- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
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IL1A Antibody IL1A/3981 recognizes interleukin 1 alpha (IL-1 alpha), a cytokine encoded by the IL1A gene. IL1A belongs to the interleukin 1 cytokine family and functions as an important mediator of inflammatory and immune responses. The protein is synthesized as a precursor that is itself biologically active and can also undergo proteolytic processing to produce a mature form.
IL-1 alpha signals through interleukin 1 receptor type 1 (IL1R1), a receptor also utilized by IL-1 beta. Receptor activation initiates intracellular signaling pathways that include NF-kappaB and MAPK signaling, promoting expression of cytokines, chemokines, adhesion molecules, and other mediators involved in inflammation and immune-cell recruitment.
A distinctive feature of IL1A biology is its role as an early signal following cellular stress, damage, or necrosis. Preformed intracellular IL-1 alpha can become available to neighboring cells following loss of membrane integrity, contributing to the initiation of sterile inflammatory responses. IL1A is therefore widely studied in innate immunity, tissue injury, inflammatory signaling, host defense, and the relationship between inflammation and tumor biology.
Clone IL1A/3981 is a mouse monoclonal antibody generated against human IL1A. This defined monoclonal reagent provides researchers with a tool for investigating interleukin 1 alpha protein expression and its involvement in inflammatory signaling. The IL-1A Antibody designation reflects an established abbreviated name for the same IL1A-encoded cytokine. NSJ Bioreagents supplies IL1A/3981 for research use only.
An IL1A Antibody can be used to investigate interleukin 1 alpha expression and molecular processes involving cytokine signaling, innate immunity, cellular injury, and inflammatory responses.
For an additional monoclonal clone with protein microarray specificity validation, see our IL-1 alpha Antibody IL1A/3982 / Interleukin 1 Alpha Antibody page.
Optimal dilution of the IL1A Antibody IL1A/3981 / IL-1A Antibody should be determined by the researcher.
A portion of amino acids 113-271 from the human protein was used as the immunogen for the IL1A Antibody IL1A/3981.
Store the IL1A Antibody IL1A/3981 at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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