- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Related Products
|
IL15 Antibody IL15/4354 recognizes interleukin 15 (IL-15), a cytokine encoded by the IL15 gene that contributes to the development, survival, and activation of several immune-cell populations. IL-15 is particularly important for natural killer (NK) cells and memory CD8-positive T cells and also influences additional lymphocyte populations. Although IL-15 shares biological activities with IL-2, the two cytokines have distinct roles in immune regulation and cellular homeostasis.
IL-15 signals through a receptor complex containing IL15RA together with the IL2RB and IL2RG receptor subunits shared with IL-2. A distinctive feature of IL-15 biology is trans-presentation, in which IL-15 bound to IL15RA on one cell is presented to IL2RB/IL2RG on a neighboring responding cell. Receptor engagement activates JAK1 and JAK3 and downstream signaling pathways that include STAT3 and STAT5, supporting lymphocyte proliferation, survival, and effector functions.
IL-15 is produced by several cell types, including monocytes, macrophages, dendritic cells, and stromal populations. Its expression and availability are tightly regulated, helping control immune-cell expansion while limiting inappropriate activation. IL-15 biology is studied extensively in innate and adaptive immunity, infectious disease, inflammatory conditions, cancer immunology, and mechanisms governing NK-cell and memory T-cell function. Because of its central role in lymphocyte biology, IL-15 and its receptor system are also investigated as potential targets for therapeutic modulation of immune responses.
Clone IL15/4354 is a mouse monoclonal antibody generated against a recombinant fragment of human IL-15. This Interleukin-15 Monoclonal Antibody provides a defined reagent for investigating IL-15 expression and complements research focused on the cytokine's roles in immune-cell signaling and regulation. NSJ Bioreagents supplies clone IL15/4354 for research use only.
An IL15 Antibody can be used to investigate IL-15 expression and its relationship to cytokine signaling, NK-cell biology, T-cell homeostasis, immune regulation, and inflammatory and antitumor immune responses.
Explore our Immunology Antibodies page for additional antibodies targeting cytokines and regulators involved in lymphocyte signaling, activation, and immune homeostasis.
Optimal dilution of the IL15 Antibody IL15/4354 / Interleukin-15 Monoclonal Antibody should be determined by the researcher.
A recombinant protein fragment was used as the immunogen for the IL15 Antibody IL15/4354.
Aliquot the IL15 Antibody IL15/4354 and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
IL-15 antibody, interleukin 15 antibody, interleukin-15 antibody, IL-T antibody, interleukin T antibody
Your bulk quote request has been submitted successfully!
Please contact us if you have any questions.