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Home >> Antibodies >> IL1 beta Antibody / IL1B

IL1 beta Antibody / IL1B [clone IL1B/6687] (V8831)

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  Catalog No Formulation Size Price (USD)  
Image V8831-100UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 100 ug 519
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V8831-20UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 20 ug 229
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V8831SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 519
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IHC staining of FFPE human adrenal gland tissue with IL1 beta antibody (clone IL1B/6687) at 2ug/ml. HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
IHC staining of FFPE human adrenal gland tissue with IL1 beta antibody (clone IL1B/6687) at 2ug/ml. HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
Availability 1-3 business days
Species Reactivity Human
Format Purified
Clonality Monoclonal (mouse origin)
Isotype Mouse IgG2b, kappa
Clone Name IL1B/6687
Purity Protein A/G affinity
UniProt P01584
Localization Cytoplasm, Extracellular (secreted)
Applications ELISA (order BSA-free format for coating) :
Immunohistochemistry (FFPE) : 1-2ug/ml
Limitations This IL1 beta antibody is available for research use only.
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Description

Recognizes a protein of 17-31kDa, identified as interleukin 1beta. It shows no cross-reaction with interleukin 1alpha. Epitopes of MAb IL1B/463 and IL1B/6687 are different and provide a good pair for developing an ELISA. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2.

Application Notes

Optimal dilution of the IL1 beta antibody should be determined by the researcher.

Immunogen

A recombinant protein fragment was used as the immunogen for the IL1 beta antibody.

Storage

Aliquot the IL1 beta antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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