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Home >> Antibodies >> IL-6 Antibody

IL-6 Antibody [clone IL6/4641] (V9751)

  Catalog No Formulation Size Price (USD)  
Image V9751-100UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 100 ug 519
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V9751-20UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 20 ug 229
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V9751SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 519
Microvalidated
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Analysis of HuProt(TM) microarray containing more than 19,000 full-length human proteins using IL-6 antibody (clone IL6/4641). These results demonstrate the foremost specificity of the IL6/4641 mAb. Z- and S- score: The Z-score represents the strength of a signal that an antibody (in combination with a fluorescently-tagged anti-IgG secondary Ab) produces when binding to a particular protein on the HuProt(TM) array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If the targets on the HuProt(TM) are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-scores. The S-score therefore represents the relative target specificity of an Ab to its intended target.
IHC staining of FFPE human tonsil tissue with IL-6 antibody (clone IL6/4641) at 2ug/ml. HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
Availability 1-3 business days
Species Reactivity Human
Format Purified
Clonality Monoclonal (mouse origin)
Isotype Mouse IgG1, kappa
Clone Name IL6/4641
Purity Protein A/G affinity
UniProt P05231
Localization Cytoplasm, Extracellular (secreted)
Applications Immunohistochemistry (FFPE) : 1-2ug/ml
Limitations This IL-6 antibody is available for research use only.
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Description

IL-6 is a potent lymphoid cell growth factor that stimulates the growth and survivability of certain B-cells and T-cells. It plays a critical role in B-cell differentiation to plasma cells and is a potent growth factor for plasmacytoma and myeloma. IL-6 is produced by a variety of cell types, including monocytes, fibroblasts and endothelial cells. Upon stimulation, macrophages, T, B, mast, and glial cells, eosinophils, keratinocytes and granulocytes also secrete IL-6.It is involved in host defense, acute phase reactions, immune responses, and hematopoiesis.

Application Notes

Optimal dilution of the IL-6 antibody should be determined by the researcher.

Immunogen

A portion of amino acids 1-200 from the human protein was used as the immunogen for the IL-6 antibody.

Storage

Aliquot the IL-6 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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