- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
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Interleukin 4 Antibody recognizes IL-4, a secreted cytokine encoded by the IL4 gene that plays an important role in regulating adaptive immunity and inflammatory responses. IL-4 is produced by several immune-cell populations and is particularly associated with type 2 immune responses. Originally characterized for its ability to stimulate B-cell proliferation, IL-4 was historically known as B cell stimulatory factor 1 (BSF-1). Its biological activities extend beyond B cells to influence lymphocyte differentiation, antibody responses, and the functional state of multiple immune-cell populations.
IL-4 signals through receptor complexes containing IL4RA (CD124). The type I IL-4 receptor pairs IL4RA with the common gamma chain IL2RG, while the type II receptor combines IL4RA with IL13RA1. Receptor activation stimulates JAK-family kinases and promotes STAT6 signaling, producing transcriptional changes that regulate immune-cell differentiation and function. The shared use of the type II receptor by IL-4 and IL-13 contributes to overlapping biological activities between these cytokines.
IL-4 is a major regulator of T helper 2 cell differentiation and contributes to B-cell activation and immunoglobulin class switching, including mechanisms associated with IgE production. It can also influence macrophage polarization and other aspects of tissue immune responses. These activities make IL-4 an important subject in research involving allergic inflammation, asthma, host defense, adaptive immunity, and mechanisms controlling communication between immune-cell populations. Dysregulated IL-4 signaling has consequently been investigated in numerous immune-mediated and inflammatory conditions.
This rabbit polyclonal antibody was generated against a peptide corresponding to amino acids 122-150 of human IL-4. As a BSF-1 Antibody, it provides a reagent for investigating the cytokine historically identified as B cell stimulatory factor 1 and its role in immune regulation. NSJ Bioreagents supplies this antibody for research use only. (nsjbio.com)
An Interleukin 4 Antibody can be used to investigate IL-4 expression and molecular mechanisms connecting cytokine signaling, lymphocyte differentiation, allergic inflammation, and adaptive immune responses.
Explore our Immunology Antibodies page for additional antibodies targeting cytokines and regulators of lymphocyte activation, differentiation, and immune signaling.
Titration of the Interleukin 4 Antibody / BSF-1 Antibody may be required due to differences in protocols and secondary/substrate sensitivity.
A portion of amino acids 122-150 from the human protein was used as the immunogen for this Interleukin 4 Antibody.
Aliquot the Interleukin 4 Antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
IL4 antibody, IL-4 antibody, interleukin 4 antibody, interleukin-4 antibody, BSF-1 antibody, BSF1 antibody, B cell stimulatory factor 1 antibody, B-cell stimulatory factor 1 antibody
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