- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
IL-4 Antibody [clone 11B11] (V8351)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V8351-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 100 ug | 539 | |
|
|
V8351-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 20 ug | 249 | |
|
|
V8351SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 539 |
|
| Availability | 1-3 business days |
| Species Reactivity | Mouse |
| Format | Purified |
| Clonality | Monoclonal (rat origin) |
| Isotype | Rat IgG1, kappa |
| Clone Name | 11B11 |
| Purity | Protein G affinity chromatography |
| UniProt | P07750 |
| Applications | ELISA (order BSA/azide-free Format) : Flow Cytometry : 1-2ug/10^6 cells in 0.1ml Immunofluorescence : 1-2ug/ml |
| Limitations | This IL-4 antibody is available for research use only. |
|
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IL-4 antibody detects interleukin-4, a cytokine encoded by the IL4 gene. IL-4 is produced primarily by Th2 cells, basophils, and mast cells, and it plays a pivotal role in promoting humoral immunity. It directs naïve CD4+ T cells toward Th2 differentiation, stimulates B-cell proliferation, and induces immunoglobulin class switching, particularly to IgE. Because of its importance in allergic disease, immunity to parasites, and regulation of inflammation, IL-4 antibody is widely used in immunology and clinical research.
IL-4 is a small glycoprotein that signals through the IL-4 receptor, composed of IL-4Rα and either the common gamma chain or IL-13Rα1. Engagement activates the JAK-STAT pathway, primarily STAT6, leading to transcription of genes that promote Th2 responses. Its activity establishes a cytokine environment that favors antibody-mediated defense and modulates macrophage polarization toward alternatively activated phenotypes.
The IL-4 antibody clone 11B11 provides specific and reproducible recognition of this cytokine. Clone 11B11 has been cited in peer-reviewed studies investigating allergic inflammation, asthma models, and helminth immunity. It has also been applied in research on autoimmunity and transplant biology, where IL-4 activity can shape immune outcomes. Its reliable performance makes it suitable for ELISA, flow cytometry, and immunohistochemistry.
Research using clone 11B11 has clarified how IL-4 contributes to pathological processes such as airway hyperreactivity and fibrosis, while also supporting protective immunity against parasitic infections. The antibody has been used to block IL-4 activity in experimental systems, providing insights into how Th2 cytokines orchestrate immune regulation. These studies highlight IL-4âs dual nature as both a protective and pathogenic mediator, depending on context.
NSJ Bioreagents supplies this IL-4 antibody to support research in allergy, immunology, and inflammation. Alternate terms include interleukin 4 antibody, B-cell stimulatory factor 1 antibody, BSF-1 antibody, Th2 cytokine antibody, IgE class switch factor antibody, and IL4 protein antibody.
Optimal dilution of the IL-4 antibody should be determined by the researcher.
Partially purified native mouse IL-4 protein was used as the immunogen for this IL4 antibody.
Store the IL-4 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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