- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
IL-3 Antibody / Interleukin 3 (R30840)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
R30840 | 0.5mg/ml if reconstituted with 0.2ml sterile DI water | 100 ug | 449 |
| Availability | 1-3 business days |
| Species Reactivity | Human, Rat |
| Format | Antigen affinity purified |
| Host | Rabbit |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit IgG |
| Purity | Antigen affinity |
| Buffer | Lyophilized from 1X PBS with 2% Trehalose |
| UniProt | P08700 |
| Applications | Western Blot : 0.5-1ug/ml Immunohistochemistry (FFPE) : 2-5ug/ml |
| Limitations | This IL-3 antibody is available for research use only. |
|
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IL-3 antibody targets Interleukin 3, encoded by the IL3 gene. Interleukin 3 is a secreted cytokine that belongs to the hematopoietic growth factor family and plays a central role in regulating blood cell development and immune cell function. IL-3 is primarily produced by activated T lymphocytes, mast cells, and other immune cells following stimulation. As a soluble signaling molecule, Interleukin 3 acts in a paracrine and autocrine manner to influence the survival, proliferation, and differentiation of multiple hematopoietic lineages.
Functionally, Interleukin 3 is a multipotent cytokine that supports the growth and expansion of early hematopoietic progenitor cells in the bone marrow. It promotes the differentiation of myeloid cells, including basophils, eosinophils, monocytes, macrophages, and dendritic cells, and contributes to mast cell development. IL-3 exerts its biological effects through binding to the IL-3 receptor complex, composed of a specific alpha subunit and a shared beta subunit that is also used by other cytokines such as GM-CSF and IL-5. An IL-3 antibody supports research focused on cytokine signaling and hematopoietic regulation.
Expression of IL3 is tightly regulated and typically induced during immune activation rather than being constitutively expressed. IL-3 production is most commonly associated with activated T cells during immune responses, particularly those involving inflammation, allergy, or infection. Through its effects on progenitor cells and mature immune cells, Interleukin 3 contributes to shaping both innate and adaptive immune responses. Its activity is important for maintaining immune cell homeostasis under conditions of stress or immune challenge.
From a biological and disease-relevance perspective, Interleukin 3 has been implicated in a range of immune-mediated and hematologic disorders. Dysregulated IL-3 signaling has been associated with allergic inflammation, asthma, and other hypersensitivity reactions due to its role in basophil and mast cell biology. IL-3 has also been studied in the context of leukemia and other myeloid malignancies, where aberrant cytokine signaling can promote abnormal cell survival and proliferation. These properties have made IL-3 an important molecule of interest in studies of immune dysregulation and hematologic disease mechanisms.
At the molecular level, Interleukin 3 is synthesized as a precursor protein of approximately 17 to 18 kDa, though its apparent molecular weight can vary depending on glycosylation and processing. As a secreted cytokine, IL-3 does not contain transmembrane domains and functions through receptor-mediated signaling pathways that activate downstream transcriptional programs. An IL-3 antibody supports research applications focused on immune signaling, cytokine biology, and hematopoietic development, with NSJ Bioreagents providing reagents intended for research use.
Variations in secondary/substrate sensitivities and test protocols may require the IL-3 antibody to be titrated for optimal performance.
An amino acid sequence from the N-terminus of human Interleukin-3 (KDGDWNEFRRKLTFYLKTLENA) was used as the immunogen for this IL-3 antibody.
After reconstitution, the IL-3 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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