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- Email: info@nsjbio.com
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This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4. [provided by RefSeq].
Titration of the IL-13 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
A portion of amino acids 118-146 from the human protein was used as the immunogen for this IL-13 antibody.
Aliquot the IL-13 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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