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Home >> Antibodies >> IkB beta Antibody / NFKBIB

IkB beta Antibody / NFKBIB (R31705)

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  Catalog No Formulation Size Price (USD)  
Image R31705 0.5mg/ml if reconstituted with 0.2ml sterile DI water 100 ug 439
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IHC staining of FFPE human breast cancer tissue with IkB beta antibody, HRP-secondary and DAB substrate. HIER: boil tissue sections in pH8 EDTA for 20 min and allow to cool before testing.
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IHC staining of FFPE human breast cancer tissue with IkB beta antibody, HRP-secondary and DAB substrate. HIER: boil tissue sections in pH8 EDTA for 20 min and allow to cool before testing.
IHC staining of FFPE human intestinal cancer tissue with IkB beta antibody, HRP-secondary and DAB substrate. HIER: boil tissue sections in pH8 EDTA for 20 min and allow to cool before testing.
IHC staining of FFPE mouse intestinal tissue with IkB beta antibody, HRP-secondary and DAB substrate. HIER: boil tissue sections in pH8 EDTA for 20 min and allow to cool before testing.
IHC staining of FFPE rat intestinal tissue with IkB beta antibody, HRP-secondary and DAB substrate. HIER: boil tissue sections in pH8 EDTA for 20 min and allow to cool before testing.
Western blot testing of 1) human HeLa, 2) human MCF7, 3) human Jurkat, 4) rat testis and 5) mouse testis tissue lysate with IkB beta antibody. Predicted molecular weight ~38 kDa.
Availability 1-3 business days
Species Reactivity Human, Mouse, Rat
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit IgG
Purity Antigen affinity
Buffer Lyophilized from 1X PBS with 2% Trehalose
UniProt Q15653
Gene ID 4793
Localization Cytoplasmic & Nuclear
Applications Western Blot : 0.5-1ug/ml
Immunohistochemistry (FFPE) : 2-5ug/ml
Limitations This IkB beta antibody is available for research use only.
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Description

IkB beta (NFKBIB) is a member of the inhibitor of kappa B family, which regulates the NF-kappaB signaling pathway. It functions by binding NF-kappaB transcription factors in the cytoplasm, preventing their nuclear translocation and subsequent activation of genes involved in immune responses, inflammation, and cell survival.

IkB beta is dynamically regulated through phosphorylation and proteasomal degradation in response to stimuli such as cytokines, stress, and pathogens. Its activity ensures proper control of NF-kappaB signaling, balancing immune defense with the prevention of excessive inflammation. Dysregulation of IkB beta has been linked to autoimmune disease, chronic inflammation, and cancer.

Using a high-quality IkB beta antibody enables reliable detection in applications such as western blot, immunohistochemistry, and immunoprecipitation. An IkB beta antibody from NSJ Bioreagents ensures sensitivity and reproducibility for studies on NF-kappaB regulation, immune signaling, and disease mechanisms. Selecting the right IkB beta antibody is essential for producing consistent and meaningful results.

Application Notes

The stated application concentrations are suggested starting amounts. Titration of the IkB beta antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

Human partial recombinant protein (AA 56-237) was used as the immunogen for this IkB beta antibody.

Storage

After reconstitution, the IkB beta antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

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