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Home >> Antibodies >> IgM Heavy Chain Antibody

IgM Heavy Chain Antibody [clone IGHM/1623] (V8791)

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  Catalog No Formulation Size Price (USD)  
Image V8791-100UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 100 ug 499
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V8791-20UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 20 ug 229
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V8791SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 519
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SDS-PAGE analysis of purified, BSA-free IgM Heavy Chain antibody (clone IGHM/1623) as confirmation of integrity and purity.
SDS-PAGE analysis of purified, BSA-free IgM Heavy Chain antibody (clone IGHM/1623) as confirmation of integrity and purity.
Availability 1-3 business days
Species Reactivity Human
Format Purified
Clonality Monoclonal (mouse origin)
Isotype Mouse IgG1, kappa
Clone Name IGHM/1623
Purity Protein A/G affinity
UniProt P01871 , P20769
Localization Cytoplasm, Cell Surface and Secreted
Applications ELISA (order BSA-free format for coating) :
Limitations This IgM Heavy Chain antibody is available for research use only.
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Description

Recognizes a protein of 75kDa, identified as mu heavy chain of human immunoglobulins. It does not cross-react with alpha (IgA), gamma (IgG), epsilon (IgE), or delta (IgD), heavy chains, T-cells, monocytes, granulocytes, or erythrocytes. Monomeric IgM is expressed as a membrane bound antibody on the surface of B cells and as a pentamer when secreted by plasma cells. IgM antibody is prominent in early immune responses to most antigens. Aberrant levels are associated with immune deficiency states, hereditary deficiencies, myeloma, Waldenstroms lymphomas. The most common feature of these malignancies is the restricted expression of a single heavy chain class. Demonstration of clonality in lymphoid infiltrates indicates that the infiltrate is clonal and therefore malignant.

Application Notes

Optimal dilution of the IgM Heavy Chain antibody should be determined by the researcher.

Immunogen

Heavy chain of human IgM was used as the immunogen for the IgM Heavy Chain antibody.

Storage

Aliquot the IgM Heavy Chain antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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