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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
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Insulin-Like Growth Factor I Receptor Antibody recognizes IGF1R, a transmembrane receptor tyrosine kinase that mediates the biological effects of insulin-like growth factors. IGF1R, also known as CD221, belongs to the insulin receptor subfamily and is synthesized as a precursor that is processed into alpha and beta subunits. The mature receptor forms a disulfide-linked heterotetramer containing two extracellular alpha chains involved in ligand binding and two membrane-spanning beta chains containing the intracellular tyrosine kinase domains.
IGF1R binds IGF1 with high affinity and also interacts with IGF2 and insulin with lower affinity. Ligand binding activates the receptor kinase and promotes autophosphorylation of intracellular tyrosine residues. Activated IGF1R subsequently phosphorylates signaling adaptor proteins, including members of the insulin receptor substrate family and SHC proteins. These events connect IGF-I receptor activation with major intracellular signaling cascades that regulate cellular proliferation, survival, metabolism, and protein synthesis.
Two major pathways downstream of IGF1R are the PI3K-AKT and RAS-MAPK signaling cascades. PI3K-AKT signaling contributes to cell survival and metabolic regulation, while RAS-MAPK signaling is closely associated with proliferation and differentiation. IGF1R can also form hybrid receptors with the insulin receptor, providing additional integration between insulin and insulin-like growth factor signaling. Because of these functions, altered IGF1R expression and signaling have been extensively investigated in cancer biology, developmental biology, metabolism, and mechanisms controlling cellular growth.
The IGF-I Receptor Antibody is a rabbit polyclonal generated against a region within amino acids 51-77 of the human protein. This N-terminal region lies within the extracellular portion of the receptor, providing a distinct immunogen location for studies of IGF1R expression. NSJ Bioreagents supplies this antibody for research use in studies of insulin-like growth factor receptor biology and associated signaling mechanisms. An Insulin-Like Growth Factor I Receptor Antibody can support investigation of IGF1R expression in research examining growth factor signaling, proliferation, survival, and cellular regulation.
For a monoclonal option with Protein Microarray Validated specificity, see our IGF1R Antibody IGF1R/4667 / Insulin-Like Growth Factor 1 Receptor Antibody page.
Titration of the Insulin-Like Growth Factor I Receptor Antibody / IGF-I Receptor Antibody may be required due to differences in protocols and secondary/substrate sensitivity.
A portion of amino acids 51-77 from the human protein was used as the immunogen for this Insulin-Like Growth Factor I Receptor Antibody.
Aliquot the Insulin-Like Growth Factor I Receptor Antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
IGF1R antibody, Insulin-like growth factor 1 receptor antibody, Insulin-like growth factor I receptor antibody, IGF-I receptor antibody, IGF1 receptor antibody, IGF-1 receptor antibody, CD221 antibody, JTK13 antibody
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