- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
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IGF1 Antibody / Somatomedin C Antibody recognizes insulin-like growth factor 1 (IGF1), a secreted peptide growth factor with structural similarity to insulin. Historically known as Somatomedin C, IGF1 is synthesized as a precursor protein that undergoes proteolytic processing to generate the mature signaling peptide. IGF1 participates in the regulation of somatic growth, cellular proliferation, differentiation, survival, and metabolic homeostasis and serves as an important mediator of growth hormone-dependent physiological effects.
IGF1 exerts many of its biological effects through binding to the insulin-like growth factor 1 receptor (IGF1R), a receptor tyrosine kinase. Ligand-dependent receptor activation stimulates intracellular signaling pathways including PI3K-AKT and RAS-MAPK, influencing cell growth, protein synthesis, glucose and lipid metabolism, and resistance to apoptosis. IGF1 activity is further regulated by a family of insulin-like growth factor binding proteins that control its stability, distribution, and availability to cell-surface receptors.
The IGF1 signaling axis is widely studied in developmental biology, metabolism, aging, and cancer. Altered IGF1 production or signaling can affect normal growth and has been associated with disorders of growth hormone action and IGF1 deficiency. Increased activity of the IGF1-IGF1R pathway has also been investigated in tumor biology because its proliferative and prosurvival signaling can influence malignant cell growth, treatment response, and disease progression. These diverse functions make Somatomedin C an important target for research into growth-factor signaling and metabolic regulation.
This rabbit polyclonal IGF1 Antibody was generated against a peptide corresponding to a portion of amino acids 115-144 of the human protein. NSJ Bioreagents offers this Somatomedin C Antibody for researchers investigating IGF1 expression and growth-factor biology. An IGF1 Antibody provides a targeted reagent for studying this secreted regulator of cellular growth, survival, development, and metabolism.
Explore our Signal Transduction Antibodies page for additional reagents targeting growth factors, receptors, and intracellular proteins involved in cellular signaling pathways.
Titration of the IGF1 Antibody / Somatomedin C Antibody may be required due to differences in protocols and secondary/substrate sensitivity.
A portion of amino acids 115-144 from the human protein was used as the immunogen for this IGF1 antibody.
Aliquot the IGF1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
IGF1 antibody, Insulin-like growth factor 1 antibody, Insulin-like growth factor I antibody, Somatomedin C antibody, IGF-I antibody
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