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Home >> Antibodies >> IgD Antibody IGHD/2730R / Heavy chain

IgD Antibody IGHD/2730R / Heavy chain [clone IGHD/2730R] (V4322)

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  Catalog No Formulation Size Price (USD)  
Image V4322-100UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 100 ug 559
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V4322-20UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 20 ug 259
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V4322SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 559
Microvalidated Recrabbitmono
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IgD Antibody IGHD/2730R in Human Serum WB. Western blot testing of human serum with IgD Antibody clone IGHD/2730R detects a strong, discrete band at approximately 65-70 kDa, consistent with the immunoglobulin delta heavy chain. The recombinant rabbit monoclonal shows minimal additional reactivity under the tested conditions, producing a clean Western blot signal. This heavy chain antibody targets IGHD, the constant region of the immunoglobulin delta heavy chain.
SDS-PAGE analysis of purified, BSA-free IgD antibody (clone IGHD/2730R) as confirmation of integrity and purity.
IHC staining of FFPE human tonsil tissue with IgD Antibody IGHD/2730R. HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
Availability 1-3 business days
Species Reactivity Human
Format Purified
Host Rabbit
Clonality Recombinant Rabbit Monoclonal
Isotype Rabbit IgG, kappa
Clone Name IGHD/2730R
Purity Protein A/G affinity
UniProt P01880
Localization Cytoplasm
Applications Immunohistochemistry (FFPE) : 1-2ug/ml for 30 minutes at RT
Western Blot : 2-4ug/ml
Limitations This IgD Antibody IGHD/2730R is available for research use only.
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Description

Immunoglobulins are four-chain, Y-shaped, monomeric structures comprised of two identical heavy chains and two identical light chains held together through interchain disulfide bonds. The chains form two domains, the Fab (antigen binding) fragment and the Fc (constant) fragment. Immunoglobulin D (IgD) exists as a monomer with delta heavy chains and either kappa or lambda light chains. It plays a biological role as a transmembrane receptor molecule, co-expressed with IgM on the surface of mature/naive B cells. In particular, it is found on spleen B cell surfaces. Compared to IgM, IgD exists in much lower numbers and is not expressed on immature B cells. IgD surface expression on B cells is regulated in part by IL-27. In mice, the inhibition of this immunoglobulin isotype does not cause a significant change to the immune system.

For detection of total human IgD, see our Recombinant Human IgD Antibody RM123 page.

Application Notes

Optimal dilution of the IgD Antibody IGHD/2730R should be determined by the researcher.

Immunogen

Recombinant full-length human IGHD protein was used as the immunogen for the IgD Antibody IGHD/2730R.

Storage

Aliquot the IgD Antibody IGHD/2730R and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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