- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
IgA Antibody CF488 Conjugate [clone IA761] (V2619CF488)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V2619CF488-100T | 500 ul at 0.1 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 Tests | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | CF488 Conjugate |
| Host | Mouse |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG1, kappa |
| Clone Name | IA761 |
| Purity | Protein G affinity chromatography |
| UniProt | P01876 |
| Localization | Cell surface, cytoplasmic, secreted |
| Applications | Flow Cytometry : 5ul/test/10^6 cells in 0.1ml Immunofluorescence : 1-2ug/ml |
| Limitations | This IgA antibody is available for research use only. |
|
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Immunoglobulin alpha heavy chain (IGHA) is the defining heavy chain component of immunoglobulin A (IgA), a major antibody class involved in mucosal immune protection. IgA antibodies are produced by differentiated B lymphocytes and plasma cells and play a critical role in defending mucosal surfaces against pathogens. The IgA Antibody CF488 Conjugate Clone IA761 recognizes the alpha heavy chain of IgA and provides a fluorescent detection reagent useful for identifying IgA-producing cells in biological samples. IgA antibodies are abundant in mucosal tissues and secretions including the gastrointestinal tract, respiratory tract, and genitourinary tract where they contribute to immune exclusion of microbes.
IgA antibody reagents are commonly used to study Immunoglobulin A, also referred to as IgA or Immunoglobulin alpha heavy chain in immunology literature. The IGHA gene encodes the heavy chain component that defines the IgA immunoglobulin class. Humans express two subclasses of IgA, IgA1 and IgA2, both of which contain the IGHA heavy chain but differ in hinge region structure and distribution among tissues. Plasma cells located in mucosa-associated lymphoid tissues such as tonsils, lymph nodes, Peyer's patches, and intestinal mucosa produce IgA antibodies that are secreted into mucosal fluids to protect epithelial surfaces from infection.
Secretory IgA is generated when polymeric IgA antibodies are transported across epithelial cells by the polymeric immunoglobulin receptor. This process results in release of IgA into mucosal secretions as a stabilized complex that includes the secretory component. In these environments IgA antibodies bind microbial antigens and toxins, preventing attachment to epithelial cells and limiting inflammatory responses that could damage mucosal tissues.
Because IgA-producing plasma cells are abundant in lymphoid tissues and mucosal immune sites, an IgA antibody is frequently used to detect plasma cell populations and characterize humoral immune responses. Fluorescently conjugated IgA antibodies such as this CF488 conjugate enable visualization of IgA-expressing cells in fluorescence microscopy and related imaging applications. Detection of Immunoglobulin alpha heavy chain expression therefore provides a useful approach for studying plasma cell distribution, mucosal immunity, and antibody-mediated immune responses in research settings.
Optimal dilution of the IgA Antibody CF488 Conjugate Clone IA761 should be determined by the researcher.
Purified human immunoglobulin alpha heavy chain was used as the immunogen for the Anti-IgA antibody.
Store the IgA antibody at 2-8oC, protected from light.
Immunoglobulin A antibody, IGHA antibody, Ig alpha heavy chain antibody, IGHA1 antibody, IGHA2 antibody
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