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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
IgA Antibody Rabbit Monoclonal AOII-9 [clone AOII-9] (RQ5074)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
RQ5074 | Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA | 100 ul | 449 |
|
| Availability | 1-2 weeks |
| Species Reactivity | Human |
| Format | Purified |
| Host | Rabbit |
| Clonality | Rabbit Monoclonal |
| Isotype | Rabbit IgG |
| Clone Name | AOII-9 |
| Purity | Affinity purified |
| UniProt | P01876 |
| Applications | Western Blot : 1:500-1:2000 |
| Limitations | This IgA antibody is available for research use only. |
|
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Immunoglobulin alpha heavy chain (IGHA) is the defining heavy chain component of immunoglobulin A (IgA), an antibody class that plays a central role in mucosal immune protection. IgA antibodies are produced by differentiated B lymphocytes and plasma cells and function as an important defense mechanism at epithelial surfaces exposed to environmental pathogens. The IgA Antibody Rabbit Monoclonal AOII-9 recognizes the alpha heavy chain of IgA and is commonly used to examine IgA-producing plasma cells and antibody-mediated immune responses in lymphoid and mucosal tissues. IgA antibodies are abundant in mucosal organs including the gastrointestinal tract, respiratory tract, and genitourinary tract where they contribute to immune defense by binding pathogens and preventing microbial attachment to epithelial surfaces.
IgA antibody reagents are widely used to detect Immunoglobulin A, also referred to as IgA or Immunoglobulin alpha heavy chain in immunology literature. The IGHA gene encodes the heavy chain that defines the IgA antibody class. Humans produce two subclasses of IgA, IgA1 and IgA2, both of which contain the IGHA heavy chain but differ in hinge region structure and tissue distribution. Plasma cells located in mucosa-associated lymphoid tissues such as tonsils, lymph nodes, Peyer's patches, and intestinal mucosa produce IgA antibodies that are secreted into mucosal fluids where they contribute to immune surveillance and pathogen neutralization.
Secretory IgA is generated when polymeric IgA antibodies interact with the polymeric immunoglobulin receptor on epithelial cells and are transported across the epithelial barrier. During this process the antibody is released into mucosal secretions as a stabilized complex containing a secretory component that protects the immunoglobulin from enzymatic degradation. In mucosal environments IgA antibodies bind microbial antigens and toxins, preventing attachment to epithelial surfaces and limiting inflammatory responses while maintaining immune protection.
Because IgA-producing plasma cells are widely distributed in lymphoid tissues and mucosal immune sites, an IgA antibody is frequently used to identify plasma cell populations and study humoral immune responses. Detection of Immunoglobulin alpha heavy chain expression provides insight into antibody production, plasma cell differentiation, and mucosal immune activity. Increased numbers of IgA-positive plasma cells may be observed in inflammatory responses, immune reactions to infection, and disorders involving B cell or plasma cell differentiation, making IGHA expression an informative marker for investigating antibody-mediated immunity.
Optimal dilution of the IgA Antibody Rabbit Monoclonal AOII-9 should be determined by the researcher.
A synthetic peptide specific to human IgA / IGHA1 was used as the immunogen for the rabbit monoclonal IgA antibody.
Store the IgA antibody at -20oC.
Immunoglobulin A antibody, IGHA antibody, Ig alpha heavy chain antibody, IGHA1 antibody, IGHA2 antibody
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