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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
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IFITM1 Antibody / Interferon Induced Transmembrane Protein Antibody recognizes IFITM1, a member of the interferon-induced transmembrane protein family that plays a central role in innate immune defense against viral infection. IFITM1 is rapidly upregulated in response to type I and type II interferons and functions as a membrane-associated restriction factor that limits the entry of numerous enveloped viruses into host cells. By altering membrane properties and endosomal trafficking, IFITM1 helps prevent viral membrane fusion and cytoplasmic entry, thereby reducing viral replication during the earliest stages of infection. In addition to its antiviral activity, IFITM1 contributes to immune regulation, cell adhesion, and cellular signaling, making an IFITM1 Antibody a valuable tool for studies of host defense, inflammation, and infectious disease.
IFITM1 is expressed in a variety of epithelial, endothelial, and immune cell populations, with expression increasing substantially following interferon stimulation. Although initially characterized for its antiviral properties, the protein has since been implicated in numerous physiological processes including immune cell activation, leukocyte migration, tissue homeostasis, and regulation of cell proliferation. IFITM1 is predominantly localized to the plasma membrane and intracellular membrane compartments, where it participates in controlling membrane dynamics and receptor-associated signaling pathways. Researchers frequently evaluate IFITM1 alongside IFITM2, IFITM3, interferon-stimulated genes, and additional innate immune markers to better understand cellular responses to viral infection and inflammatory signaling. An IFITM1 Antibody is therefore widely employed to investigate interferon-responsive pathways and membrane-associated immune mechanisms.
Altered IFITM1 expression has been reported in numerous human cancers, including colorectal, gastric, breast, lung, cervical, and head and neck malignancies. In many tumor types, elevated expression has been associated with enhanced cell proliferation, invasion, migration, resistance to therapy, and poor clinical outcome. IFITM1 has also been linked to epithelial-to-mesenchymal transition, tumor progression, and interactions between malignant cells and the immune microenvironment. Beyond oncology, abnormal regulation of IFITM1 has been investigated in autoimmune disorders, chronic inflammatory diseases, and viral infections, where dysregulated interferon signaling contributes to disease pathogenesis. Consequently, an IFITM1 Antibody is an important reagent for research spanning immunology, oncology, virology, and inflammation.
IFITM1 is routinely analyzed using Western blot, immunohistochemistry, immunofluorescence, flow cytometry, and immunoprecipitation to evaluate protein expression, membrane localization, and regulation following cytokine stimulation or viral challenge. Its inducible expression and broad involvement in innate immune signaling make it a useful biomarker for studying host-pathogen interactions and interferon-mediated cellular responses. NSJ Bioreagents offers carefully validated antibodies to support these diverse applications across multiple experimental models. An IFITM1 Antibody / Interferon Induced Transmembrane Protein Antibody provides researchers with a dependable tool for investigating antiviral defense mechanisms, interferon signaling, immune regulation, and disease-associated changes in membrane protein expression.
Explore our Innate Immunity Antibodies page to discover validated antibodies for IFITM1 and other proteins involved in interferon signaling, antiviral defense, immune regulation, and host-pathogen interactions.
The stated application concentrations are suggested starting amounts. Titration of the IFITM1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
An amino acid sequence from the N-terminus of human IFITM1 (MHKEEHEVAVLGPPPST) was used as the immunogen for this IFITM1 antibody.
After reconstitution, the IFITM1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
IFITM1 antibody, Interferon Induced Transmembrane Protein antibody, CD225 antibody, Interferon Induced Transmembrane Protein 1 antibody
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