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Home >> Antibodies >> IDH1-R132H Mutant Antibody

IDH1-R132H Mutant Antibody [clone IDH1.R132H/8205R] (V4937)

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  Catalog No Formulation Size Price (USD)  
Image V4937-100UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 100 ug 519
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V4937-20UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 20 ug 229
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V4937SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 519
Microvalidated Recrabbitmono
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IHC staining of FFPE human prostate tissue with IDH1-R132H mutation with IDH1-R132H Mutant antibody (clone IDH1.R132H/8205R). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
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IHC staining of FFPE human prostate tissue with IDH1-R132H mutation with IDH1-R132H Mutant antibody (clone IDH1.R132H/8205R). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
SDS-PAGE analysis of purified, BSA-free IDH1-R132H Mutant antibody (clone IDH1.R132H/8205R).
Availability 1-3 business days
Species Reactivity Human
Format Purified
Clonality Recombinant Rabbit Monoclonal
Isotype Rabbit IgG, kappa
Clone Name IDH1.R132H/8205R
Purity Protein A/G affinity
UniProt O75874
Localization Cytoplasm, Nucleus
Applications Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT
Limitations This IDH1-R132H Mutant antibody is available for research use only.
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Description

IDH1 R132H antibody binds to IDH1-mutated protein, but does not bind the wild-type IDH1 protein. IDH1 R132H point mutations are frequently seen in World Health Organization grade II and III gliomas and are believed to constitute an early step in tumorigenesis. IDH1 R132H can be used as a diagnostic marker to help differentiate infiltrating gliomas from gliosis, and as a prognostic marker for gliomas and secondary glioblastoma multiforme. IDH1 R132H antibody shows strong cytoplasmic staining and weaker nuclear staining in tumor cells with the R132H-mutated peptide. Diffuse staining of the fibrillary tumor matrix is also seen.

Application Notes

Optimal dilution of the IDH1-R132H Mutant antibody should be determined by the researcher.

Immunogen

A recombinant partial protein sequence (within amino acids 1-200) from the human protein was used as the immunogen for the IDH1-R132H Mutant antibody.

Storage

Aliquot the IDH1-R132H Mutant antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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