- Tel: 858.663.9055
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
IDE Antibody / Insulin degrading enzyme [clone AOOB-9] (RQ5434)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
 |
RQ5434 | Antibody in PBS with 0.02% sodium azide and 50% glycerol | 100 ul | 429 |
|
| Availability | 1-2 weeks |
| Species Reactivity | Human |
| Format | Purified |
| Clonality | Rabbit Monoclonal |
| Isotype | Rabbit IgG |
| Clone Name | AOOB-9 |
| Purity | Affinity purified |
| UniProt | P14735 |
| Applications | Western blot : 1:500-1:2000 |
| Limitations | This IDE antibody is available for research use only. |
|
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The IDE gene encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [RefSeq]
Optimal dilution of the IDE antibody should be determined by the researcher.
A synthetic peptide specific to human Insulin-degrading enzyme / IDE was used as the immunogen for the IDE antibody.
Store the IDE antibody at -20oC.
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