Human IL-10 Antibody (R30116)

Description

Interleukin-10 (IL-10) is a key anti-inflammatory cytokine that plays a central role in regulating immune responses and maintaining immune homeostasis. Produced by a variety of cell types, including T cells, B cells, monocytes, and dendritic cells, IL-10 functions to suppress the expression of pro-inflammatory cytokines, limit antigen presentation, and inhibit the activation of macrophages and dendritic cells. These immunosuppressive effects are critical for preventing excessive tissue damage during infection and for controlling autoimmune inflammation.

Human IL-10 is particularly important in resolving inflammatory responses and promoting tissue repair. Dysregulation of IL-10 production or signaling has been associated with chronic inflammatory diseases, including inflammatory bowel disease, rheumatoid arthritis, and systemic lupus erythematosus. Due to its role in immune modulation, IL-10 is also a focus of research in cancer, transplantation, and infectious diseases.

The human IL-10 antibody is an essential tool for detecting IL-10 expression in various experimental settings, including ELISA, flow cytometry, western blot, and immunohistochemistry. Researchers use the human IL-10 antibody to quantify cytokine levels, monitor immune activation, and investigate disease pathogenesis. With high sensitivity and specificity, the human IL-10 antibody supports both basic research and clinical studies aimed at understanding and modulating immune responses.

Application Notes

The stated application concentrations are suggested starting amounts. Titration of the human IL-10 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

Interleukin-10 partial recombinant protein (AA 19-178) was used as the immunogen for this human IL-10 antibody.

Storage

After reconstitution, the human IL-10 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.