- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
HSD11B1 Antibody / Glucocorticoid Metabolism Enzyme (R36132)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
R36132-100UG | 0.5 mg/ml in 1X TBS, pH7.3, with 0.5% BSA (US sourced) and 0.02% sodium azide | 100 ug | 475 |
| Availability | 1-3 business days |
| Species Reactivity | Mouse |
| Predicted Reactivity | Rat |
| Format | Antigen affinity purified |
| Host | Goat |
| Clonality | Polyclonal (goat origin) |
| Isotype | Goat Ig |
| Purity | Antigen affinity |
| Gene ID | 15483 |
| Applications | Western Blot : 0.3-1ug/ml ELISA (peptide) LOD : 1:32000 |
| Limitations | This HSD11B1 Antibody / Glucocorticoid Metabolism Enzyme is available for research use only. |
|
Review this product on BioCompare and get a $20 Amazon gift card
|
Related Products
|
Hydroxysteroid 11-beta dehydrogenase 1 (HSD11B1) is an NADPH-dependent oxidoreductase encoded by the HSD11B1 gene and functions as a key regulator of intracellular glucocorticoid metabolism. HSD11B1 Antibody / Glucocorticoid Metabolism Enzyme is useful for studying cortisol activation, steroid hormone regulation, metabolic signaling, inflammatory responses, and endocrine pathway biology. HSD11B1 is also widely known as 11beta-HSD1 and catalyzes conversion of inactive cortisone into biologically active cortisol within peripheral tissues.
HSD11B1 antibody, also referred to as 11beta-HSD1 antibody, Hydroxysteroid 11-beta dehydrogenase 1 antibody, or Cortisone reductase antibody in the literature, recognizes a microsomal enzyme localized primarily to the endoplasmic reticulum. HSD11B1 is highly expressed in metabolic and endocrine tissues including liver, adipose tissue, lung, brain, and glucocorticoid-responsive epithelial cell populations. Through regulation of local glucocorticoid availability, HSD11B1 contributes to tissue-specific control of inflammatory signaling, glucose metabolism, adipocyte differentiation, and stress-responsive transcriptional programs.
HSD11B1 plays an important role in metabolic homeostasis and has been extensively studied in obesity, insulin resistance, metabolic syndrome, type 2 diabetes, and cardiovascular disease. Increased HSD11B1 activity may elevate intracellular cortisol concentrations and contribute to dysregulated lipid metabolism, adipose tissue expansion, and chronic inflammatory signaling. The enzyme has additionally been implicated in pulmonary inflammation, neurodegenerative disease, hepatic metabolism, and glucocorticoid-associated immune regulation.
11beta-HSD1 functions together with hexose-6-phosphate dehydrogenase and additional endoplasmic reticulum-associated metabolic enzymes involved in steroid hormone metabolism and redox regulation. The protein is predominantly localized within the lumen of the endoplasmic reticulum where it supports glucocorticoid activation in metabolically active tissues. In western blot studies, HSD11B1 is commonly detected near its predicted molecular weight, although additional bands may occur due to post-translational modification, oligomerization, or processing-related migration differences.
HSD11B1 is encoded on human chromosome 1q32 and produces a member of the short-chain dehydrogenase/reductase superfamily containing conserved catalytic motifs involved in steroid metabolism. The enzyme participates in pathways regulating glucocorticoid signaling, inflammatory adaptation, lipid homeostasis, and cellular responses to endocrine stress. Because glucocorticoid activation influences numerous physiologic and pathologic processes, HSD11B1 remains an important target in endocrine, metabolic, and inflammation-related research.
This goat polyclonal HSD11B1 antibody has been supported using knockout-validated and peptide-blocking western blot approaches in mouse lung tissue lysates. Knockout analysis demonstrates loss of the expected approximately 32 kDa endogenous HSD11B1 signal in knockout tissue relative to wild-type controls, supporting selective target detection. Additional peptide-blocking studies show inhibition of both the expected approximately 32 kDa band and an additional approximately 45 kDa immunoreactive species following incubation with the immunizing peptide, further supporting specificity for HSD11B1-related protein detection in research applications.
Explore our Knockdown Validated Antibodies page for additional antibodies supported by gene silencing or knockout validation strategies to help confirm target-specific signal detection in western blot, immunofluorescence, and related research applications.
Optimal dilution of the HSD11B1 Antibody / Glucocorticoid Metabolism Enzyme should be determined by the researcher.
Amino acids TARSEEGLQKVVSR were used as the immunogen for this HSD11B1 Antibody.
Aliquot and store the HSD11B1 Antibody at -20oC.
11beta-HSD1 antibody, HSD11 beta 1 antibody, Hydroxysteroid 11-beta dehydrogenase 1 antibody, Cortisone reductase antibody, HSD11B1 cortisol activation enzyme antibody
Your bulk quote request has been submitted successfully!
Please contact us if you have any questions.
Powered by Bioz
