HOXA3 Antibody / Developmental Patterning Transcription Factor Antibody (R30681)

HOXA3 Antibody Human SW620 WB. Western blot analysis of HOXA3 expression was performed using anti-HOXA3 antibody in human SW620 cell lysate. HOXA3 is a homeobox transcription factor that regulates developmental gene expression, anterior-posterior patterning, tissue specification, and organogenesis during vertebrate embryogenesis. A specific immunoreactive band is detected at approximately 46 kDa, consistent with the predicted molecular weight of HOXA3. Expression in SW620 colorectal adenocarcinoma cells is consistent with reports implicating dysregulated HOXA3 in tumor progression, cellular differentiation, and tissue remodeling. These results support the utility of HOXA3 Antibody for studies of developmental transcriptional regulation, stem cell biology, angiogenesis, and cancer research.

HOXA3 Antibody Human Pancreatic Cancer IHC. IHC staining of FFPE human pancreatic cancer tissue with HOXA3 antibody demonstrated predominantly nuclear staining in malignant epithelial cells, consistent with the localization of HOXA3 as a homeobox transcription factor that regulates developmental gene expression and cellular differentiation. HOXA3 plays essential roles in embryonic patterning, tissue specification, angiogenesis, and stem cell function, while dysregulated expression has been associated with multiple human malignancies, including pancreatic cancer. The observed nuclear staining supports the transcriptional regulatory function of HOXA3 and its involvement in tumor progression and tissue remodeling. HIER was performed by steaming tissue sections in pH 6 citrate buffer for 20 minutes followed by cooling prior to staining. These results support the utility of HOXA3 Antibody for studies of developmental biology, transcriptional regulation, angiogenesis, and cancer research.