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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
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HOXA10 Antibody / Developmental Transcription Factor Antibody recognizes HOXA10, a member of the highly conserved HOX family of homeobox transcription factors that regulate embryonic development, body patterning, and tissue differentiation. HOXA10 functions as a sequence-specific DNA-binding protein that controls the expression of genes responsible for establishing positional identity along the anterior-posterior axis during embryogenesis. Through precise regulation of developmental transcriptional programs, HOXA10 directs morphogenesis of the axial skeleton, reproductive tract, kidneys, and other developing tissues. As a master developmental regulator, HOXA10 is essential for normal vertebrate organogenesis and cellular differentiation.
HOXA10 continues to play important biological roles after embryonic development, particularly within the female reproductive system where it regulates endometrial differentiation, uterine receptivity, embryo implantation, and fertility. The protein also contributes to hematopoietic stem cell maintenance, mesenchymal differentiation, tissue remodeling, and regeneration. Expression of HOXA10 is tightly controlled by developmental signaling pathways and epigenetic mechanisms, allowing appropriate activation of lineage-specific gene expression programs during both development and adult tissue homeostasis. Because of these diverse functions, HOXA10 Antibody / Developmental Transcription Factor Antibody is a valuable tool for investigations of developmental biology, reproductive biology, and transcriptional regulation.
Abnormal HOXA10 expression has been implicated in numerous diseases including endometriosis, infertility, leukemia, ovarian cancer, endometrial carcinoma, colorectal cancer, and acute myeloid leukemia. Dysregulated HOXA10 activity can alter cell proliferation, differentiation, migration, and stem cell function, contributing to disease progression and tumor development. Consequently, HOXA10 has emerged as both a clinically relevant biomarker and a potential therapeutic target in reproductive medicine, developmental disorders, and oncology. Ongoing research continues to define its role in regulating gene expression networks that govern normal development and disease.
HOXA10 Antibody / Developmental Transcription Factor Antibody supports studies of embryonic development, transcriptional regulation, reproductive biology, stem cell biology, developmental signaling, and cancer research. Researchers frequently use HOXA10 Antibody / Developmental Transcription Factor Antibody to investigate HOX gene function, tissue specification, organogenesis, and mechanisms controlling cellular differentiation. Its central role in developmental gene regulation makes HOXA10 an important marker for both basic and translational biomedical research.
Explore our Stem Cell Antibodies page to learn more about proteins that regulate stem cell maintenance, cellular differentiation, and developmental gene expression.
Optimal dilution of the HOXA10 Antibody / Developmental Transcription Factor Antibody should be determined by the researcher.
Amino acids PQATSCSFAQNIKE were used as the immunogen for this HOXA10 antibody.
Aliquot and store the HOXA10 antibody at -20oC.
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