- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
HLA-DRB1 Antibody Rabbit Polyclonal (RQ4649)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
RQ4649 | 0.5mg/ml if reconstituted with 0.2ml sterile DI water | 100 ug | 449 |
|
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Antigen affinity purified |
| Host | Rabbit |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit IgG |
| Purity | Antigen affinity purified |
| Buffer | Lyophilized from 1X PBS with 2% Trehalose and 0.025% sodium azide |
| UniProt | P13761 |
| Applications | Western Blot : 0.5-1ug/ml |
| Limitations | This HLA-DRB1 antibody is available for research use only. |
|
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Major histocompatibility complex class II DR beta 1 (HLA-DRB1) is a transmembrane glycoprotein encoded by the HLA-DRB1 gene that forms the beta chain of the HLA-DR antigen receptor complex involved in peptide antigen presentation to CD4-positive T lymphocytes. HLA-DRB1 Antibody Rabbit Polyclonal targets this immune receptor component and supports detection of HLA-DR beta chain expression in research studies examining antigen-presenting cells and immune activation pathways. HLA-DR belongs to the major histocompatibility complex class II family of cell surface receptors responsible for presenting processed extracellular peptide antigens to helper T lymphocytes. The functional receptor is composed of two chains: an alpha chain encoded by HLA-DRA and a beta chain encoded primarily by HLA-DRB1. Together these chains form a heterodimeric complex that binds peptides generated within endosomal antigen-processing compartments and displays them on the cell surface for recognition by T-cell receptors. Through this mechanism, HLA-DR molecules play a central role in adaptive immune responses and immune surveillance. Expression of HLA-DR is characteristic of professional antigen-presenting cells including B lymphocytes, macrophages, dendritic cells, and activated monocytes. Because these immune cell populations regulate antigen presentation and immune activation, HLA-DRB1 expression is frequently studied in immunology, inflammation, and tumor immunology research. The HLA-DRB1 gene is highly polymorphic and exhibits extensive allelic diversity across human populations, contributing to variation in peptide-binding specificity and immune recognition. Numerous HLA-DRB1 variants have been associated with susceptibility to autoimmune diseases and immune-mediated disorders, including rheumatoid arthritis, multiple sclerosis, and type 1 diabetes. As a result, antibodies targeting HLA-DRB1 are widely used to investigate immune cell activation, antigen presentation pathways, and immune infiltration within tissues. A rabbit polyclonal antibody recognizing HLA-DRB1 can detect the HLA-DR beta chain in research applications examining immune cell populations, antigen-presenting cell biology, and regulation of adaptive immune responses.
Optimal dilution of the HLA-DRB1 Antibody Rabbit Polyclonal should be determined by the researcher.
Amino acids TERVQFLERLFYNQEEFVRFDSDVGEYRAVTELGR were used as the immunogen for the HLA-DRB1 antibody.
After reconstitution, the HLA-DRB1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
HLA-DR beta antibody, HLA-DRB1 antibody, MHC class II DR beta antibody, HLA class II histocompatibility antigen DR beta antibody
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