- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
HLA-DRB1 Antibody Clone DA2 / HLA-DRB1 Monoclonal Antibody [clone DA2] (V7845)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V7845-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 100 ug | 559 | |
|
|
V7845-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 20 ug | 259 | |
|
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V7845SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG2b, kappa |
| Clone Name | DA2 |
| Purity | Protein G affinity chromatography |
| UniProt | P01911 |
| Applications | Flow Cytometry : 1-2ug/10^6 cells Immunofluorescence : 1-2ug/ml Western Blot : 1-2ug/ml Immunohistochemistry (FFPE) : 1-2ug/ml |
| Limitations | This HLA-DRB1 antibody is available for research use only. |
|
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Major histocompatibility complex class II DR beta 1 (HLA-DRB1) is a transmembrane glycoprotein encoded by the HLA-DRB1 gene that forms the beta chain of the HLA-DR antigen receptor responsible for presenting processed peptide antigens to CD4-positive helper T lymphocytes. HLA-DRB1 Antibody Clone DA2 recognizes the HLA-DR beta chain and has been widely described in the literature as Clone DA2, a mouse monoclonal antibody frequently used to investigate major histocompatibility complex class II expression and antigen presentation in immune cells. The HLA-DR receptor is a heterodimeric complex composed of an alpha chain encoded by HLA-DRA paired with a polymorphic beta chain encoded by HLA-DRB genes, most prominently HLA-DRB1. Together these chains form a peptide-binding receptor that displays extracellularly derived antigens on the cell surface for recognition by CD4-positive helper T lymphocytes, a process essential for activation of adaptive immune responses.
Expression of HLA-DR molecules is characteristic of professional antigen-presenting cells including B lymphocytes, macrophages, dendritic cells, and activated monocytes. Because of this expression pattern, HLA-DRB1 antibodies are widely used in immunology research to identify antigen-presenting immune cell populations and evaluate immune activation states within tissues and cultured cells. Clone DA2 has been reported in numerous peer-reviewed studies examining the distribution and function of MHC class II molecules on immune cells. In these studies, HLA-DRB1 Antibody Clone DA2 has been used to characterize antigen-presenting cell populations and to study regulation of immune responses mediated through the HLA-DR pathway.
The HLA-DRB1 gene exhibits extensive allelic diversity across human populations, contributing to variability in peptide binding specificity and immune responsiveness. Numerous HLA-DRB1 variants influence susceptibility to autoimmune diseases and immune-mediated disorders including rheumatoid arthritis, multiple sclerosis, and type 1 diabetes. Because HLA-DRB1 plays a central role in antigen presentation and immune regulation, antibodies such as HLA-DRB1 Antibody Clone DA2 are widely used in immunology research examining antigen presentation pathways, immune activation, and immune cell function.
Optimal dilution of the HLA-DRB1 Antibody Clone DA2 should be determined by the researcher.
Activated human peripheral blood mononuclear cells were used as the immunogen for the HLA-DRB1 antibody.
Store the HLA-DRB1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
HLA-DR beta antibody, HLA-DRB1 antibody, MHC class II DR beta antibody, HLA class II histocompatibility antigen DR beta antibody
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