- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
HLA-DR Antibody Recombinant Rabbit MAb for IHC HLA-DRA/8286R [clone HLA-DRA/8286R] (V5134)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V5134-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
|
|
V5134-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
|
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V5134SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
|
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Rabbit |
| Clonality | Recombinant Rabbit Monoclonal |
| Isotype | Rabbit IgG, kappa |
| Clone Name | HLA-DRA/8286R |
| Purity | Protein A/G affinity |
| UniProt | P01903 |
| Localization | Cell surface |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT |
| Limitations | This HLA-DR antibody is available for research use only. |
|
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Human leukocyte antigen DR alpha (HLA-DRA) is a major histocompatibility complex class II protein encoded by the HLA-DRA gene and forms the alpha chain of the HLA-DR antigen receptor responsible for presenting peptide antigens to CD4-positive T lymphocytes. HLA-DR Antibody Recombinant Rabbit MAb for IHC recognizes the HLA-DR antigen complex and supports immunohistochemistry analysis of MHC class II expression within tissue sections containing antigen-presenting immune cells.
HLA-DR is a heterodimeric receptor composed of the HLA-DRA alpha chain paired with a beta chain encoded by HLA-DRB genes. These two chains associate to form the HLA-DR antigen complex that binds peptides derived from extracellular proteins processed within endosomal compartments. The peptide-loaded HLA-DR receptor is transported to the cell surface where it presents antigenic peptides to CD4-positive helper T lymphocytes. Through this antigen presentation pathway, the HLA-DR complex plays a central role in adaptive immune activation and immune surveillance.
In immunology literature the HLA-DR receptor complex is commonly referred to simply as HLA-DR, and antibodies targeting this molecule are frequently described as HLA-DR antibodies, HLA-DR alpha antibodies, or MHC class II DR antibodies. HLA-DR antibody reagents therefore detect the HLA-DR antigen complex expressed on professional antigen-presenting cells including B lymphocytes, macrophages, and dendritic cells. Expression of HLA-DR alpha can also be induced by inflammatory cytokines such as interferon-gamma, leading to increased MHC class II expression during infection, autoimmune disease, inflammatory responses, and within tumor microenvironments where immune cells infiltrate tissues.
Immunohistochemistry detection of HLA-DR expression provides a useful approach for visualizing antigen-presenting immune cells within tissue architecture. Analysis of HLA-DR positive cells in tissue sections helps characterize immune infiltration, lymphoid structures, and antigen presentation activity in both normal and pathological tissues. Recombinant rabbit monoclonal clone HLA-DRA/8286R recognizes the HLA-DR antigen complex and supports detection of HLA-DR expressing immune cells in immunohistochemistry studies.
Optimal dilution of the HLA-DR antibody should be determined by the researcher.
A recombinant partial protein sequence (within amino acids 1-200) from the human protein was used as the immunogen for the HLA-DR antibody.
Aliquot the HLA-DR antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
HLA-DR alpha antibody, HLA-DRA antibody, MHC class II DR antibody, HLA-DR antigen antibody
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