- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
HLA-DQA1 Antibody ACEC-8 / MHC Class II DQ Alpha Antibody [clone ACEC-8] (RQ4988)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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RQ4988 | Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA | 100 ul | 449 |
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| Availability | 1-2 weeks |
| Species Reactivity | Human |
| Format | Purified |
| Host | Rabbit |
| Clonality | Rabbit Monoclonal |
| Isotype | Rabbit IgG |
| Clone Name | ACEC-8 |
| Purity | Affinity purified |
| UniProt | P01909 |
| Applications | Western Blot : 1:1000-1:5000 |
| Limitations | This HLA-DQA1 Antibody ACEC-8 / MHC Class II DQ Alpha Antibody is available for research use only. |
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HLA-DQA1 Antibody ACEC-8 / MHC Class II DQ Alpha Antibody targets HLA-DQA1, which encodes an alpha-chain component of the human HLA-DQ major histocompatibility complex (MHC) class II molecule. HLA-DQ functions in adaptive immunity by presenting processed antigenic peptides to CD4-positive T lymphocytes. The HLA-DQA1 protein associates with an HLA-DQB beta chain to form a heterodimeric HLA-DQ complex, with both chains contributing to the peptide-binding region responsible for antigen presentation.
HLA-DQA1 is located within the highly polymorphic MHC region on chromosome 6. Sequence variation within HLA-DQA1, together with polymorphism of its partnering HLA-DQB genes, generates structurally diverse HLA-DQ molecules with different peptide-binding properties. The resulting alpha/beta combinations influence which antigenic peptides can be efficiently presented to T cells and contribute to substantial interindividual variation in adaptive immune recognition.
Functional HLA-DQ complexes participate in the MHC class II antigen-processing pathway. Proteins internalized by antigen-presenting cells are degraded within intracellular compartments, allowing selected peptides to associate with class II molecules. Peptide-loaded HLA-DQ heterodimers are subsequently transported to the plasma membrane, where they can be surveyed by CD4-positive T lymphocytes. This process contributes to immune surveillance, helper T cell activation and regulation of antigen-specific immune responses.
HLA-DQA1 has particular importance in immunogenetics because specific combinations of HLA-DQA1 and HLA-DQB1 alleles are associated with differences in disease susceptibility and antigen recognition. HLA-DQA1 Antibody reagents provide a chain-focused approach to investigating the HLA-DQ system, complementing antibodies that recognize the assembled HLA-DQ antigen or broader MHC class II determinants. HLA-DQA1 is relevant to research involving antigen presentation, autoimmunity, transplantation, infectious disease and adaptive immune regulation.
Clone ACEC-8 is a rabbit monoclonal antibody directed against human HLA-DQA1. NSJ Bioreagents provides this HLA-DQA1 Antibody for research into HLA-DQ alpha-chain biology and MHC class II antigen presentation. An MHC Class II DQ Alpha Antibody can support investigation of the HLA-DQA1 component of HLA-DQ and its contribution to peptide presentation and CD4 T cell-mediated immune recognition.
For additional information on HLA-DQA1 biology and complementary antibody validation, visit our HLA-DQA1 Antibody / HLA-DQ Alpha 1 Chain Antibody page.
Optimal dilution of the HLA-DQA1 Antibody ACEC-8 / MHC Class II DQ Alpha Antibody should be determined by the researcher.
A synthetic peptide specific to human HLA-DQA1 was used as the immunogen for the HLA-DQA1 antibody.
Store the HLA-DQA1 antibody at -20oC.
HLA-DQA1 antibody, DQA1 antibody, HLA-DQ Alpha 1 Chain antibody, HLA-DQ Alpha Chain antibody, MHC Class II DQ Alpha antibody
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