- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
HLA-DQ Antibody SPV-L3 / MHC Class II Antibody [clone SPV-L3] (V2581)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V2581-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 100 ug | 559 | |
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V2581-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 20 ug | 259 | |
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V2581SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG2a, kappa |
| Clone Name | SPV-L3 |
| Purity | Protein G affinity chromatography |
| UniProt | P01908 , P01909 , P01920 |
| Localization | Cell surface |
| Applications | Flow Cytometry : 1-2ug/million cells Immunofluorescence : 1-2ug/ml |
| Limitations | This HLA-DQ Antibody SPV-L3 / MHC Class II Antibody is available for research use only. |
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HLA-DQ Antibody SPV-L3 / MHC Class II Antibody recognizes human HLA-DQ, a classical major histocompatibility complex (MHC) class II molecule that functions in antigen presentation to CD4-positive T lymphocytes. HLA-DQ contributes to adaptive immune recognition by displaying processed antigenic peptides at the cell surface, where peptide-MHC complexes can be surveyed by T cell receptors. Recognition of an appropriate complex promotes helper T cell activation and contributes to the coordination of cellular and humoral immune responses.
HLA-DQ is a heterodimer composed of an alpha chain encoded principally by HLA-DQA1 and a beta chain encoded by HLA-DQB1. Both chains contribute to formation of the extracellular peptide-binding groove. Extensive polymorphism within HLA-DQ influences the repertoire of peptides that can be presented and contributes to differences in immune recognition among individuals. Particular HLA-DQ alleles and haplotypes have been associated with susceptibility or resistance to multiple immune-mediated diseases, making HLA-DQ an important focus in immunogenetics and autoimmune disease research.
HLA-DQ is expressed predominantly by professional antigen-presenting cells, including B lymphocytes, dendritic cells and macrophages. Expression can also be induced or enhanced in additional cell types in response to inflammatory signaling. Antigens internalized by antigen-presenting cells are processed primarily within endosomal compartments, where resulting peptides can be loaded onto MHC class II molecules before peptide-HLA complexes are transported to the plasma membrane for CD4 T cell recognition.
HLA-DQ Antibody reagents are useful for investigating MHC class II expression, antigen-presenting cell populations and HLA-DQ-dependent immune recognition. HLA-DQ biology is particularly relevant to studies of autoimmunity, infectious disease, transplantation, inflammation and adaptive immune regulation. Antibodies directed against HLA-DQ also complement reagents targeting HLA-DP and HLA-DR, allowing researchers to distinguish individual components of the classical MHC class II system from broader pan-HLA class II expression.
Clone SPV-L3 is an established mouse monoclonal antibody directed against human HLA-DQ and has been extensively used in published research. NSJ Bioreagents provides this HLA-DQ Antibody for studies of MHC class II biology, antigen presentation and immune-cell recognition. An MHC Class II Antibody targeting HLA-DQ can support investigation of HLA-DQ-positive cell populations and mechanisms connecting peptide presentation with CD4 T cell-mediated immunity.
Explore our Immunology Antibodies page for additional reagents targeting MHC molecules, antigen presentation and adaptive immune responses.
Optimal dilution of the HLA-DQ Antibody SPV-L3 / MHC Class II Antibody should be determined by the researcher.
The T4-positive CTL clone HG-38 was used as the immunogen for the HLA-DQ Antibody SPV-L3.
Store the HLA-DQ Antibody SPV-L3 at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
HLA-DQ antibody, MHC Class II antibody, HLA Class II DQ antibody, HLA-DQ MHC II antibody, SPV-L3 antibody
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