- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Pan-HLA Class II Antibody HLA-Pan/8622R / HLA-DP/DQ/DR Antibody [clone HLA-Pan/8622R] (V5137)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V5137-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
|
|
V5137-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
|
|
V5137SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Rabbit |
| Clonality | Recombinant Rabbit Monoclonal |
| Isotype | Rabbit IgG, kappa |
| Clone Name | HLA-Pan/8622R |
| Purity | Protein A/G affinity |
| UniProt | P04440 , P01908 , P01909 , P01920 , P01903 |
| Localization | Cell Surface |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT |
| Limitations | This HLA-DP/DQ/DR antibody is available for research use only. |
|
Review this product on BioCompare and get a $20 Amazon gift card
|
Related Products
|
Pan-HLA Class II Antibody HLA-Pan/8622R / HLA-DP/DQ/DR Antibody recognizes HLA-DP, HLA-DQ and HLA-DR, the three principal groups of classical human MHC class II molecules. These proteins enable antigen-presenting cells to display processed peptides to CD4-positive T lymphocytes, providing a critical step in the development of antigen-specific immune responses. MHC class II-mediated recognition influences helper T cell activation and subsequent regulation of B cells, macrophages and other components of immunity.
HLA class II molecules are composed of alpha and beta transmembrane glycoproteins that associate to form functional heterodimers. The extracellular regions of both chains contribute to the peptide-binding groove, while their membrane-spanning and cytoplasmic regions anchor the complex at the cell surface. Peptide loading occurs predominantly within specialized intracellular compartments following uptake and processing of extracellular antigens.
Professional antigen-presenting cells such as dendritic cells, B lymphocytes and macrophages constitutively express MHC class II molecules. Expression can also be induced in other cell populations during inflammatory responses. This regulated expression helps determine which cells can participate directly in class II-restricted antigen presentation and provides a mechanism through which cytokine signaling can modify interactions between immune cells and CD4-positive T lymphocytes.
Simultaneous recognition of HLA-DP, HLA-DQ and HLA-DR is useful when broad MHC class II detection is preferable to analysis of an individual HLA locus. Pan-HLA class II reagents can therefore complement locus-specific antibodies in studies comparing overall class II expression with the contributions of particular HLA molecules. MHC class II expression and regulation are relevant to research in immunology, inflammatory disease, transplantation, infection and tumor immunity.
Clone HLA-Pan/8622R is a recombinant rabbit monoclonal antibody characterized for broad recognition of human HLA-DP, HLA-DQ and HLA-DR. NSJ Bioreagents provides this Pan-HLA Class II Antibody for research into antigen presentation, immune-cell activation and MHC class II regulation. An HLA-DP/DQ/DR Antibody can support investigation of class II-positive cells and CD4 T cell-dependent immune responses.
For additional information on HLA class II biology and complementary antibody validation, visit our HLA-DP/DQ/DR Antibody CR3/43 / MHC Class II Antibody page.
Optimal dilution of the HLA-DP/DQ/DR antibody should be determined by the researcher.
Priess cells (a human B cell line) were used as the immunogen for the HLA-DP/DQ/DR antibody.
Aliquot the HLA-DP/DQ/DR antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Your bulk quote request has been submitted successfully!
Please contact us if you have any questions.
Powered by Bioz
Citations(23)
