- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
HLA-DP Antibody SPM421 / HLA Class II DP Antibody [clone SPM421] (V2579)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V2579-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 100 ug | 559 | |
|
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V2579-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 20 ug | 259 | |
|
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V2579SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
|
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG2b, kappa |
| Clone Name | SPM421 |
| Purity | Protein G affinity chromatography |
| UniProt | P04440 |
| Localization | Cell surface |
| Applications | ELISA (order BSA/sodium Azide-free Format For Coating) : Flow Cytometry : 1-2ug/10^6 cells |
| Limitations | This HLA-DP Antibody SPM421 / HLA Class II DP Antibody is available for research use only. |
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HLA-DP Antibody SPM421 / HLA Class II DP Antibody recognizes a non-polymorphic determinant of HLA-DP, a member of the major histocompatibility complex class II family. HLA-DP molecules participate in adaptive immunity by presenting processed antigenic peptides to CD4-positive T lymphocytes. Recognition of peptide-HLA-DP complexes by T cell receptors contributes to antigen-specific lymphocyte activation and helps coordinate cellular and humoral immune responses.
HLA-DP is a heterodimeric cell-surface glycoprotein composed of an alpha chain encoded by HLA-DPA1 and a beta chain encoded by HLA-DPB1. The alpha and beta chains associate non-covalently, with their extracellular domains forming the peptide-binding groove characteristic of MHC class II molecules. Peptides generated through endosomal processing can be loaded into this groove before peptide-HLA-DP complexes are transported to the cell surface for recognition by CD4-positive T cells.
HLA-DP belongs to the classical MHC class II group together with HLA-DR and HLA-DQ. Genetic polymorphism within HLA-DP contributes to variation in peptide-binding preferences and antigen-specific immune responses among individuals. HLA-DP expression and genetic variation have been investigated in transplantation, infectious disease, autoimmune and inflammatory conditions, cancer immunology and other areas involving adaptive immune recognition.
Expression of HLA-DP and other MHC class II molecules is associated with antigen-presenting cells and can vary according to cellular differentiation and immune activation. Differences in MHC class II expression among normal and malignant lymphoid populations have therefore been investigated as features of immune-cell development and lymphoproliferative disease. HLA-DP analysis can also contribute to studies examining the regulation of antigen presentation and communication between antigen-presenting cells and helper T lymphocytes.
Clone SPM421 is a mouse monoclonal antibody generated using the human REH6 acute lymphoblastic leukemia cell line and is characterized as recognizing a non-polymorphic determinant of DP-MHC class II. NSJ Bioreagents provides this HLA-DP Antibody for research into HLA-DP expression, antigen presentation and immune-cell biology. An HLA Class II DP Antibody can support investigation of MHC class II-mediated peptide presentation and CD4 T cell immune responses.
For additional information on HLA-DP biology and complementary antibody validation, visit our HLA-DP Antibody HLA-DPB1/2862R / MHC Class II DP Antibody page.
Optimal dilution of the HLA-DP Antibody SPM421 / HLA Class II DP Antibody should be determined by the researcher.
Non-T, non-B human acute lymphoblastic leukemia REH6 cell line was used as the immunogen for the HLA-DP Antibody SPM421.
Store the HLA-DP Antibody SPM421 at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
HLA-DP antibody, HLA Class II DP antibody, HLA-DPB1 antibody, MHC Class II DP antibody, HLA-DP beta antibody
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