- Tel: 858.663.9055
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
HLA-DPB1 Antibody (F54283)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
 |
F54283-0.4ML | In 1X PBS, pH 7.4, with 0.09% sodium azide | 0.4 ml | 399 | |
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F54283-0.08ML | In 1X PBS, pH 7.4, with 0.09% sodium azide | 0.08 ml | 185 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit Ig |
| Purity | Antigen affinity purified |
| UniProt | P04440 |
| Localization | Cell surface |
| Applications | Western blot : 1:500-1:2000 Immunohistochemistry (FFPE) : 1:25 Flow cytometry : 1:25 (1x10e6 cells) |
| Limitations | This HLA-DPB1 antibody is available for research use only. |
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HLA-DPB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules.
The stated application concentrations are suggested starting points. Titration of the HLA-DPB1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
A portion of amino acids 77-105 from the human protein were used as the immunogen for the HLA-DPB1 antibody.
Aliquot the HLA-DPB1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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